Impact of preterm birth on infant mortality for newborns with congenital heart defects: The EPICARD population-based cohort study

BMC Pediatrics
Enora LaasEPICARD Study Group

Abstract

Congenital heart defects (CHD) and preterm birth (PTB) are major causes of infant mortality. However, limited data exist on risk of mortality associated with PTB for newborns with CHD. Our objective was to assess impact of PTB on risk of infant mortality for newborns with CHD, while taking into account the role of associated anomalies and other potentially confounding factors. We used data on 2172 live births from a prospective population-based cohort study of CHD (the EPICARD Study) and compared neonatal, post-neonatal and overall infant mortality for infants born at <32, 32-34 and 35-36 weeks vs. those born at term (37-41 weeks). Preterm newborns had a 3.8-fold higher risk of infant death (17.9%) than term newborns (4.7%), RR 3.8, 95%CI 2.7-5.2; the risk associated with PTB was more than four-fold higher for neonatal (RR 4.3, 95% CI 2.9-6.6) and three-fold higher for post-neonatal deaths (RR 3.0, 95% CI 1.7-5.2). Survival analysis showed that newborns <35 weeks had a higher risk of mortality, which decreased but persisted after exclusion of associated anomalies and adjustment for potential confounders. Preterm birth is associated with an approximately four-fold higher risk of infant mortality for newborns with CHD. This exces...Continue Reading

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Citations

Feb 26, 2019·World Journal for Pediatric & Congenital Heart Surgery·Richard A Jonas
Mar 15, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Kristin N FergusonBrett J Manley
Oct 7, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniela AndersonFabio Carmona
Sep 28, 2020·The Journal of Pediatrics·Niels B MatthiesenTine B Henriksen
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May 30, 2019·Developmental Neuroscience·Charlotte Holme NielsenPer Torp Sangild
Oct 17, 2021·Acta Paediatrica·Ioana Dumitrascu BirisGrenville Fox

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Software Mentioned

R Development Core Team
EPICARD
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