Impact of pretransplant infections on clinical outcomes of liver transplant recipients

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Hsin-Yun SunNina Singh

Abstract

Whether pretransplant nonviral infections influence outcomes after transplantation in liver transplant recipients in the current era is not well defined. One hundred consecutive patients undergoing liver transplantation in 2005-2008 were studied. Demographics, posttransplant clinical events, and mortality were compared between recipients with and without infections within 12 months before transplantation. In all, 32% of the patients (32/100) developed 45 episodes of pretransplant infections, which included spontaneous bacterial peritonitis (35.6%), bloodstream infections (28.9%), cellulitis (13.3%), pneumonia (8.9%), urinary tract infections (6.7%), and other infections (6.7%). Compared with 68 recipients without pretransplant infections, those with infections had a higher Model for End-Stage Liver Disease score and a lower likelihood of transplantation from home and required longer and more frequent hospital care before and after transplantation (P < 0.05). Mortality at 90 (9.4% versus 2.9%) and 180 days (15.6% versus 10.3%) post-transplant did not differ significantly between recipients with and without pretransplant infections (P = not significant). A higher Model for End-Stage Liver Disease score (P < 0.05) and posttranspla...Continue Reading

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Citations

Apr 21, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James Y FindlayJean Emond
Mar 16, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marcelino González-PadillaJulián Torre-Cisneros
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Jul 30, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Madeleine R HeldmanMichael G Ison
Jun 17, 2014·Critical Care Medicine·Kenneth J Woodside
May 5, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jonel TrebickaVicente Arroyo
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Aug 14, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rosa Martin Mateos, Agustín Albillos
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Nov 20, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Vinayak Nikam, Manish Srivastava
Nov 20, 2020·Transplantation·Constantine J KarvellasEmmanuel Weiss

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