Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: insight from cardiovascular magnetic resonance

Journal of the American College of Cardiology
Marco FranconeLuciano Agati

Abstract

We investigated the extent and nature of myocardial damage by using cardiovascular magnetic resonance (CMR) in relation to different time-to-reperfusion intervals. Previous studies evaluating the influence of time to reperfusion on infarct size (IS) and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) have yielded conflicting results. Seventy patients with STEMI successfully treated with primary percutaneous coronary intervention within 12 h from symptom onset underwent CMR 3 +/- 2 days after hospital admission. Patients were subcategorized into 4 time-to-reperfusion (symptom onset to balloon) quartiles: < or =90 min (group I, n = 19), >90 to 150 min (group II, n = 17), >150 to 360 min (group III, n = 17), and >360 min (group IV, n = 17). T2-weighted short tau inversion recovery and late gadolinium enhancement CMR were used to characterize reversible and irreversible myocardial injury (area at risk and IS, respectively); salvaged myocardium was defined as the normalized difference between extent of T2-weighted short tau inversion recovery and late gadolinium enhancement. Shorter time-to-reperfusion (group I) was associated with smaller IS and microvascular obstruction and larger salvaged my...Continue Reading

References

Apr 1, 1996·Radiology·O P SimonettiD A Henry
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Thorsten ReffelmannRobert A Kloner
Jul 21, 2004·Journal of the American College of Cardiology·Bernard R Chaitman, Michael J Lim
May 11, 2005·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Olga BondarenkoAlbert C van Rossum
Aug 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Hassan Abdel-AtyMatthias G Friedrich
Apr 19, 2008·Journal of the American College of Cardiology·Matthias G FriedrichRainer Dietz
Oct 18, 2008·Journal of the American College of Cardiology·Elliott M Antman

❮ Previous
Next ❯

Citations

Dec 7, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ali YilmazUdo Sechtem
Nov 30, 2012·Current Treatment Options in Cardiovascular Medicine·C El KhouryE Bonnefoy
Jun 29, 2010·Antioxidants & Redox Signaling·Javier InserteDavid Garcia-Dorado
Mar 19, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kiyotaka ImotoSatoshi Morita
Nov 30, 2010·European Heart Journal·Martina Perazzolo MarraSabino Iliceto
Mar 15, 2011·European Heart Journal·Juerg Schwitter, Andrew E Arai
May 21, 2011·BMC Cardiovascular Disorders·Mona SchlyterMargareta Östman
Feb 22, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ingo Eitel, Matthias G Friedrich
Mar 26, 2013·PloS One·Luciano de AndradeMaria Dalva de Barros Carvalho
Sep 10, 2011·Drugs·Marco Valgimigli, Monica Minarelli
Aug 24, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Rasmus HesselfeldtLars S Rasmussen
Jun 3, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Jamal N KhanGerry P McCann
Oct 26, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Chrishan J NalliahPramesh Kovoor
May 9, 2014·European Heart Journal Cardiovascular Imaging·Sophia Hammer-HansenAndrew E Arai
May 25, 2011·Journal of Thrombosis and Thrombolysis·Eliano Pio NavareseSilvio Klugmann
Nov 4, 2015·Nature Reviews. Cardiology·Xuming DaiGeorge A Stouffer
Apr 15, 2011·La Presse médicale·Hervé Le Breton
Dec 2, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Reuben M ThomasBradley H Strauss
Jan 19, 2016·Global Cardiology Science & Practice·Jan Bogaert, Ingo Eitel
Sep 10, 2015·The American Journal of Emergency Medicine·Ju Yeon HeoYoung Sun Ro
Apr 19, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Tomoe HagioMaria I Altbach
Sep 17, 2011·JACC. Cardiovascular Imaging·Matthias G FriedrichRaymond J Kim
Feb 24, 2015·International Journal of Cardiology·M Polańska-SkrzypczykA Witkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.