Abstract
A large number of patients treated at our hospital for endocarditis have negative cultures. Taking into consideration the fact that many of these patients receive antibiotics prior to referral, we decided to study culture-negative endocarditis in Pakistan. The medical records of all patients admitted to the Aga Khan University Hospital, Pakistan, for the period from 1988 to 2001, with an underlying diagnosis of infective endocarditis (IE) and negative cultures, were reviewed. Of the 159 patients diagnosed with IE by revised Duke criteria, 86 (54.1%) had persistent negative cultures. More than half of these patients (52%) had received antibiotics before being referred to our center. Patients with culture-negative endocarditis were less likely to be classified as definite endocarditis by revised Duke criteria (p<0.001, 95% CI 0.07-0.3) or to have large vegetations (p=0.021, 95% CI 0.05-0.5), and more likely to have a mitral valve prolapse (p=0.003, 95% CI 1.6-2.3). Definite endocarditis (p=0.042, 95% CI 1.02-7.4), heart failure (p=0.008, 95% CI 1.4-12.7), renal failure (p=0.017, 95% CI 1.16-40.7), embolism (p=0.019, 95% CI 1.2-38.8), and neurological complications (p=0.02, 95% CI 1.16-9.2) were associated with an increased mortal...Continue Reading
References
Jan 1, 1979·The American Journal of Medicine·E L Pesanti, I M Smith
Dec 1, 1992·The American Journal of Cardiology·R ChoudhuryR P Sapru
Apr 30, 1992·The New England Journal of Medicine·A R Tunkel, D Kaye
Oct 1, 1966·Medical Times·E A Stead
Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B HoenP Canton
Nov 1, 1994·Progress in Cardiovascular Diseases·A S AliM Lesch
Dec 1, 1995·Journal of Clinical Pathology·J P Burnie, I Clark
Jul 1, 1997·European Heart Journal·E CecchiA Brusca
Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C C Lamas, S J Eykyn
Feb 12, 1998·The Journal of Infection·P D Barnes, D W Crook
Jun 11, 1999·Journal of the American College of Cardiology·G HabibR Luccioni
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S LiG R Corey
Jun 22, 2000·Heart·R O NetzerA Cerny
May 4, 2001·International Journal of Cardiology·M SadiqS A Sheikh
Jun 9, 2001·The American Journal of Cardiology·J ZamoranoL Sánchez-Harguindey
Apr 20, 2002·The International Journal of Health Planning and Management·S SiddiqiR Sauerborn
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Bruno HoenUNKNOWN Association pour l'Etude et la Prévention de l'Endocardite Infectieuse (AEPEI) Study Group
Feb 20, 2003·Heart·C C Lamas, S J Eykyn
Apr 28, 2004·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Muhammad TariqRaymond A Smego
Feb 3, 2005·International Journal of Cardiology·Naveen GargNakul Sinha
Mar 11, 2005·Indian Journal of Pediatrics·Sunil KarandeMadhuri Kulkarni
May 17, 2005·Heart·G Y ShinA S Breathnach
Oct 12, 2005·Heart·B D Prendergast
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ellen Jo BaronLucy S Tompkins
Citations
Aug 6, 2010·Internal Medicine·Joel BranchEri Tanaka
Jul 10, 2012·Revista Española De Cardiología·Carlos FerreraJosé Alberto San Román
Jun 28, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rinaldo Focaccia SicilianoTania Mara Varejao Strabelli
Sep 30, 2016·The Journal of Antimicrobial Chemotherapy·Estelle MenuDidier Raoult
Dec 20, 2014·Expert Review of Molecular Diagnostics·John J FarrellRobert A Bonomo
Nov 7, 2019·The Pan African Medical Journal·Varsha Vekaria-HiraniRachel Musoke
Apr 9, 2021·Annals of Vascular Surgery·Jihee KangYang-Jin Park