Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohn's disease

Inflammatory Bowel Diseases
Daniel J SteinDavid G Binion

Abstract

Infliximab is efficacious in the management of moderate to severe Crohn's disease (CD). There are limited data regarding performance of infliximab in patients who require reinitiation of maintenance dosing following previous irregular exposure. This was a retrospective, observational study of CD patients treated with maintenance infliximab beyond 3 years. Maintenance infliximab infusion regimens were categorized as scheduled maintenance (SM) (maintenance infusions q < or =8 weeks after loading) or prior irregular (PI) (no loading, gap in therapy >8 weeks prior to or during maintenance therapy). We examined differences in need for medical and surgical hospitalizations as well as associated healthcare costs between the 2 groups. In all, 104 CD patients met criteria for 3-year maintenance infliximab treatment (SM n = 64; PI n = 40). The rates of CD-related surgeries (60.9% and 55.0%, P = not significant [N.S.]) and medical hospitalizations (35.9% and 37.5%, P = N.S.) prior to infliximab initiation was similar between the 2 groups. However, the rate of medical (26.5% versus 47.5%, P = 0.035) and surgical hospitalizations (21.8% versus 48.7%, P = 0.009) were significantly lower in the SM compared to the PI group. During the third ye...Continue Reading

References

May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Mar 10, 2000·The American Journal of Gastroenterology·C N BernsteinJ F Blanchard
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
May 10, 2003·The American Journal of Gastroenterology·Teresa LongobardiCharles N Bernstein
Feb 6, 2004·Gastroenterology·Paul RutgeertsStephen B Hanauer
Feb 27, 2004·The New England Journal of Medicine·Bruce E SandsSander J van Deventer
May 29, 2004·Gastroenterology·Paul RutgeertsSéverine Vermeire
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Stephen B HanauerPaul Rutgeerts
Apr 9, 2005·Journal of Clinical Gastroenterology·Brian G FeaganStephen Hanauer
Feb 17, 2006·Gut·S P L TravisUNKNOWN European Crohn's and Colitis Organisation
Jun 6, 2007·Current Treatment Options in Gastroenterology·Brian W Behm, Stephen J Bickston
Dec 14, 2007·The American Journal of Gastroenterology·Ashwin N AnanthakrishnanDavid G Binion
Apr 10, 2008·Inflammatory Bowel Diseases·F MargoC Costa Santos
Jun 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletJean-Frédéric Colombel
Apr 9, 2009·The American Journal of Gastroenterology·Jean-Frédéric ColombelParvez M Mulani

❮ Previous
Next ❯

Citations

Jul 29, 2017·Alimentary Pharmacology & Therapeutics·M EberhardsonO Olén
Sep 1, 2017·Journal of Digestive Diseases·Laura MartelliLaurent Peyrin-Biroulet
Jun 17, 2018·Mucosal Immunology·Sudarshan ParamsothyJean-Frederic Colombel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.