Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
S S ChavesLyn Finelli

Abstract

Patients hospitalized with influenza may require extended care on discharge. We aimed to explore predictors for extended care needs and the potential mitigating effect of antiviral treatment among community-dwelling adults aged ≥ 65 years hospitalized with influenza. We used laboratory-confirmed influenza hospitalizations from 3 influenza seasons. Extended care was defined as new placement in a skilled nursing home/long-term/rehabilitation facility on hospital discharge. We focused on those treated with antiviral agents to explore the effect of early treatment on extended care and hospital length of stay using logistic regression and competing risk survival analysis, accounting for time from illness onset to hospitalization. Treatment was categorized as early (≤ 4 days) or late (>4 days) in reference to date of illness onset. Among 6593 community-dwelling adults aged ≥ 65 years hospitalized for influenza, 18% required extended care at discharge. The need for care increased with age and neurologic disorders, intensive care unit admission, and pneumonia were predictors of care needs. Early treatment reduced the odds of extended care after hospital discharge for those hospitalized ≤ 2 or >2 days from illness onset (adjusted odds r...Continue Reading

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Citations

May 20, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen ArriolaSandra S Chaves
Jul 1, 2016·Current Opinion in Infectious Diseases·Philippe VanhemsElodie Munier-Marion
Feb 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joshua D DoyleJill M Ferdinands
Apr 17, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julio RamirezAlicia M Fry
Dec 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace D AppiahAngela P Campbell
Nov 26, 2019·Journal of Infection Prevention·Fran Brooke-Pearce, Elli Demertzi
Apr 14, 2020·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Lin DouHemang Yadav

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