Impact of protecting ligands on surface structure and antibacterial activity of silver nanoparticles

Langmuir : the ACS Journal of Surfaces and Colloids
J Daniel PadmosPeng Zhang

Abstract

Silver nanoparticles (Ag NPs) have attracted much attention in the past decade because of their unique physicochemical properties and notable antibacterial activities. In particular, thiol-protected Ag NPs have come to the forefront of metal nanoparticle studies, as they have been shown to possess high stability and interesting structure-property relationships. However, a clear correlation between thiol-protecting ligands, the resulting Ag NP surface structure, and their antibacterial properties has yet to be determined. Here, a multielement (Ag and S), multi-edge (Ag K-edge, Ag L3-edge, S K-edge) X-ray absorption spectroscopy (XAS) methodology was used to identify the structure and composition of Ag NPs protected with cysteine. XAS characterization was carried out on similar-sized Ag NPs protected with poly(vinylpyrrolidone) (PVP), in order to provide a valid comparison of the ligand effect on surface structure. The PVP-Ag NPs showed a metallic Ag surface and composition, consistent with metal NPs protected by weak protecting ligands. On the other hand, the Cys-Ag NPs exhibited a distinct surface shell of silver sulfide, which is remarkably different than previously studied Cys-Ag NPs. The minimum inhibitory concentration (MIC...Continue Reading

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Citations

May 8, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Renee V GorehamIngo Köper
Apr 10, 2016·Biochimica Et Biophysica Acta·Giulia Rossi, Luca Monticelli
Sep 1, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Wei-Chang ChangDe-Hao Tsai
Nov 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunming LiLigang Yin
Feb 22, 2017·Physical Chemistry Chemical Physics : PCCP·Alexander KyrychenkoOleg N Kalugin

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