Impact of protein malnutrition on exogenous reinfection with Mycobacterium tuberculosis.

Infection and Immunity
D N McMurrayC L Mintzer

Abstract

Malnutrition may be a predisposing host factor in the development of exogenous-reinfection tuberculosis. Outbred Hartley guinea pigs were given isocaloric diets containing either 30% ovalbumin (control animals) or 10% ovalbumin (low-protein-fed [LP] animals). Equal numbers of control and LP animals were assigned to one of three infection groups: (i) primary pulmonary infection with a low-virulence, streptomycin-resistant (LVsr) isolate of Mycobacterium tuberculosis and then reinfection 6 weeks later by the same route with a high-virulence (HV) isolate; (ii) only the primary infection (LVsr isolate); and (iii) only the secondary infection (HV isolate). Each infection resulted in the development of 4 to 12 pulmonary tubercles. Guinea pigs were skin tested with purified protein derivative and killed 6 weeks after the second infection. Protein deprivation suppressed the dermal responses to purified protein derivative in all infection groups. Primary infection of well-nourished animals with the LVsr isolate induced significant protection against infection with the HV isolate in the reinfected group, based upon the numbers of viable mycobacteria in the lung and spleen. Protein malnutrition did not exacerbate disease in the reinfected...Continue Reading

Citations

Jan 1, 1990·Annals of the New York Academy of Sciences·D N McMurrayE Hernandez-Frontera
Jun 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Ashwin S Dharmadhikari, Edward A Nardell
Jun 24, 2014·Osong Public Health and Research Perspectives·Sara KimSunmi Lee
Jun 1, 1991·Alcoholism, Clinical and Experimental Research·J Weinberg, T R Jerrells
Jun 1, 2000·Theoretical Population Biology·Z FengA F Capurro
Oct 27, 2005·Tuberculosis·U D Gupta, V M Katoch

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