Impact of psychotic features on morbidity and course of illness in patients with bipolar disorder

European Psychiatry : the Journal of the Association of European Psychiatrists
I OzyildirimO Yazici

Abstract

In this study, we aimed to compare the clinical features and response patterns to the long-term prophylaxis of bipolar patients with or without psychotic features. The life charts of patients with bipolar I disorder were evaluated. Two hundred and eighty-one patients who suffer with bipolar disorder for at least 4 years and who had at least three mood episodes were included to the study. The patients whose all episodes are psychotic (psychotic group) and the patients who never experienced psychotic episode (non-psychotic group) were assigned as comparison groups. The clinical features and the response to long-term prophylaxis were compared across the groups. The psychotic group consists of 43 patients; non-psychotic group consists of 54 patients. The history of bipolar disorder among the first-degree relatives was remarkably more prevalent in non-psychotic group (p=0.032). The predominance of manic/hypomanic episodes was significantly higher in psychotic group than non-psychotic group; and the rate of depressive episodes were higher in non-psychotic group than psychotic group (p=0.013). Episodes were more severe (p<0.001) and hospitalization rates were higher (p=0.023) in psychotic group. The response to lithium monotherapy was...Continue Reading

References

Dec 1, 1979·Journal of Affective Disorders·N E RosenthalR R Fieve
Jul 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·R A O'ConnellB E O'Brien
Dec 1, 1990·Archives of General Psychiatry·M TohenM T Tsuang
Apr 1, 1990·Archives of General Psychiatry·W H BerrettiniS Detera-Wadleigh
Mar 1, 1995·The American Journal of Psychiatry·J F GoldbergL S Grossman
Jun 20, 1996·Journal of Affective Disorders·M MajL Magliano
Nov 7, 1999·The Psychiatric Clinics of North America·L SanchezR Weller
Jan 11, 2000·Journal of Affective Disorders·O YaziciN Turan
Feb 15, 2000·The American Journal of Psychiatry·G A CarlsonS Sievers
May 1, 2001·The American Journal of Psychiatry·M F GrunebaumJ J Mann
May 16, 2001·Archives of General Psychiatry·F BellivierF Schürhoff
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·James B PotashJ Raymond DePaulo
Aug 19, 2003·Comprehensive Psychiatry·Paul E KeckRobert M Post
Apr 20, 2004·Journal of Affective Disorders·Mani N PavuluriJohn A Sweeney
May 19, 2005·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Richard RendeJean-François Allaire
Feb 1, 2006·Journal of Affective Disorders·Sheila C CaetanoJair C Soares
Jul 4, 2006·Journal of Affective Disorders·Richard RendeMartin Keller
Apr 20, 2007·Journal of Affective Disorders·Julie GarnhamMartin Alda

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Citations

Aug 6, 2013·Bipolar Disorders·Ameena T AhmedRoger S McIntyre
Mar 26, 2013·Bipolar Disorders·Sofie Ragnhild AminoffIngrid Melle
Jan 13, 2018·Depression and Anxiety·Marco Antonio CaldieraroAndrew A Nierenberg
Jan 20, 2019·The Australian and New Zealand Journal of Psychiatry·Alfredo Carlo AltamuraUNKNOWN ISBD Italian Chapter Epidemiological Group
Jul 23, 2013·Indian Journal of Endocrinology and Metabolism·Sanjay KalraK M Prasanna Kumar
Feb 25, 2014·The Tohoku Journal of Experimental Medicine·Yasuhiro MoriSunao Kaneko
Apr 4, 2017·European Archives of Psychiatry and Clinical Neuroscience·A Carlo AltamuraEmilio Sacchetti
Oct 12, 2018·Psychological Medicine·Annet H van BergenMarco P M Boks

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