Impact of pulmonary and extrapulmonary tuberculosis infection in kidney transplantation: a nationwide population-based study in Taiwan

Transplant Infectious Disease : an Official Journal of the Transplantation Society
S-M OuT-J Chen

Abstract

Tuberculosis (TB) has been reported to increase morbidity after kidney transplantation and pose a therapeutic challenge. However, population-based research, specifically focused on the association between kidney transplantation and subsequent pulmonary or extrapulmonary TB, is lacking. A nationwide population-based study was conducted using Taiwan's National Health Insurance Research Database, which provided claims data belonging to kidney transplant recipients during 1997-2006. Multivariate analysis was used to identify independent risk factors for TB after kidney transplantation. Kaplan-Meier survival analysis was used to assess the outcome of patients with TB. Among 4554 kidney transplant recipients over the 10-year period, 109 (2.4%) patients with newly diagnosed TB were identified: 75 patients with only pulmonary involvement, and 34 with extrapulmonary spread. The incidence of kidney transplant recipients developing TB was 638 per 100,000 person-years. The independent risk factors for post-transplant TB included cyclosporine-based immunosuppressant agents during the first year after kidney transplantation (odds ratio [OR]: 1.98, P = 0.001), hepatitis C infection (OR: 1.79, P = 0.024), and chronic obstructive pulmonary dise...Continue Reading

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Citations

Jan 11, 2013·The American Journal of Tropical Medicine and Hygiene·Elizabeth De Francesco DaherElvino José Guardão Barros
Nov 27, 2015·The British Journal of Radiology·Marisa PereiraBruno Hochhegger
Apr 16, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Noémie Boillat-BlancoUNKNOWN ESCMID Study Group of Infection in Compromised Hosts
Jan 3, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·W BoschS Pungpapong
Apr 16, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C-Y ChenC-C Yang
Apr 16, 2018·Clinical Transplantation·Cybele Lara R Abad, Raymund R Razonable
Jun 12, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Julien GrasJean Michel Molina
Jul 17, 2014·The Journal of Rheumatology·Shuo-Ming OuChia-Jen Liu
Feb 14, 2018·BMJ Open·Yung-Feng YenDachen Chu
Feb 21, 2018·Emerging Infectious Diseases·Yung-Feng YenWei-Juin Su
May 4, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sehoon ParkHajeong Lee

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