PMID: 7482734Oct 27, 1995

Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor

Transplantation
P G BeattyE L Milford

Abstract

As successful organ or marrow transplantation correlates with the degree of HLA-compatibility between patient and donor, registries have been developed to facilitate matching. However, racial minority groups have a lower chance of finding a match. We evaluate the impact of the biology of racial genetic polymorphism upon the probability of finding an HLA match for patients of different racial groups. The National Marrow Donor Program has compiled the HLA types of 20,449 patients and 1,625,159 potential volunteer donors. These HLA types were used to estimate the probability of finding an HLA-matched donor for patients of different racial groups. We estimated the HLA haplotype frequencies for different races, and then determined the probability of finding matched donors, given several hypothetical registry sizes. We confirmed that patients of minority races searching the current National Marrow Donor Program registry have low probabilities of finding matches. This was only partly due to the smaller number of donors from these racial minorities, as the observation persisted even when hypothetical donor registry sizes were the same for all racial groups. We demonstrate that African-Americans are more polymorphic with respect to HLA,...Continue Reading

Citations

Dec 20, 2000·Transplantation Proceedings·Z YouhuaW Liming
May 20, 1999·Transplantation Proceedings·R K Gupta, M Jain
Mar 7, 2000·Tissue Antigens·M M CollinsC K Hurley
Mar 8, 2003·Tissue Antigens·E PetersdorfJ A Hansen
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·E PetersdorfJ A Hansen
Jun 13, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J de OteroA Pahissa
Dec 22, 1999·Journal of Pediatric Hematology/oncology·M C Walters
Jun 22, 2010·American Journal of Clinical Oncology·Margaret M ByrneMichael C Cheung
Jun 1, 1997·Immunological Reviews·J A HansenC Anasetti
Aug 6, 2008·Bone Marrow Transplantation·H J Symons, E J Fuchs
Sep 28, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Franco Aversa
Feb 23, 1999·Human Immunology·E HsuC K Hurley
Aug 1, 1997·Human Immunology·J M Cecka
Jan 19, 2002·Seminars in Hematology·Massimo F MartelliYair Reisner
May 16, 2014·Journal of Medical Ethics·Gregory M T GuilcherSteven Joffe
Jul 22, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexander DewKoen van Besien
Feb 28, 2015·Kidney International·Vikas R Dharnidharka, Michael E Seifert
Apr 15, 2011·Immunological Reviews·Maria-Grazia RoncaroloRosa Bacchetta
Jun 12, 2010·Annals of the New York Academy of Sciences·Katia PerruccioAndrea Velardi

Related Concepts

HLA Typing
HLA Antigens
Genetic Polymorphism
Tissue Donors
Organ Transplantation

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