PMID: 8581297Dec 1, 1995Paper

Impact of rearrangements on function and position of chromosomes in the interphase nucleus and on human genetic disorders

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
M B Qumsiyeh

Abstract

A synthesis of numerous published data and my own observations reveal that chromatin structure in interphase is functional, dynamic and complex. I hypothesize that: (1) chromosome regions organize nuclear structures and thus their own environment (address themselves in sites and condensation patterns most appropriate for their functional state in the particular cell); (2) chromosome rearrangement could alter nuclear architecture and thus function; and (3) these ideas can explain the contribution of chromosome rearrangements, even in a balanced form, to human pathologic conditions.

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Citations

Mar 31, 2004·Annales de génétique·María G DomínguezHoracio Rivera
Jan 5, 2000·Cancer Genetics and Cytogenetics·M B QumsiyehX X Zhang
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Sep 17, 2004·International Journal of Radiation Biology·I R Radford
Nov 24, 1999·Genomics·A Ashley-KochM A Pericak-Vance
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Nov 26, 1999·American Journal of Industrial Medicine·G PiligianM Cherniack
Aug 1, 1999·Evolution; International Journal of Organic Evolution·Noureddine ChattiJean-Christophe Auffray

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