Impact of recombination on genetic variability within Staphylococcus aureus clonal complexes

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Nevena Basic-HammerDominique S Blanc

Abstract

The population structure of Staphylococcus aureus is generally described as highly clonal and is consequently subdivided into several clonal complexes (CCs). Recent data suggested that recombination might occur more frequently within than among CCs. To test this hypothesis as well as to understand how genetic diversity is created in S. aureus, we analyzed a collection of 182 isolates with MLST and five highly variable core adhesion (ADH) genes. As expected the polymorphism of ADH genes was higher than MLST genes. However both categories of genes showed low within CCs diversity with a dominant haplotype and its single nucleotide variants. Several recombination events were detected but none involved intra-CC recombination. This did not confirm the hypothesis of higher recombination within CCs. Nevertheless, molecular analyses of variance indicated that these few recombination events have a significant impact on the genetic diversity within CCs. In addition, although most ADH genes were under purifying selection, signs of positive selection associated with a recombinant group were detected. These data highlight the importance of recombination on the evolution of the highly clonal S. aureus and suggest that recombination when combi...Continue Reading

References

Feb 1, 1992·Journal of Molecular Evolution·J M Smith
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M SmithB G Spratt
Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
Dec 22, 1999·Virology·M PadidamC M Fauquet
Oct 26, 2000·Molecular Ecology·M ClementK A Crandall
Jun 23, 2001·Molecular Biology and Evolution·C J BrownP Joyce
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D Posada, K A Crandall
Apr 19, 2002·Molecular Biology and Evolution·David Posada
May 20, 2003·Journal of Bacteriology·Edward J FeilNicholas P J Day
Nov 25, 2003·Nature Reviews. Genetics·Michael P H Stumpf, Gilean A T McVean
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·D Ashley Robinson, Mark C Enright
Dec 12, 2003·Bioinformatics·Julio RozasRicardo Rozas
Feb 6, 2004·Journal of Bacteriology·D Ashley Robinson, Mark C Enright
May 21, 2004·Nature Reviews. Microbiology·Edward J Feil
Jul 28, 2004·Trends in Microbiology·Jessica E Cooper, Edward J Feil
Sep 21, 2004·Bioinformatics·D P MartinD Posada
Feb 4, 2005·Molecular Biology and Evolution·Ziheng YangRasmus Nielsen
Apr 5, 2005·Journal of Bacteriology·Austin L Hughes, Robert Friedman
Oct 14, 2005·Molecular Biology and Evolution·Daniel H Huson, David Bryant
Oct 21, 2005·Journal of Theoretical Biology·William P HanageBrian G Spratt
Nov 22, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kevin de Queiroz
Feb 21, 2006·Bioinformatics·Jochen Maydt, Thomas Lengauer
May 17, 2006·Trends in Ecology & Evolution·Fabien HalkettFrançois Balloux
Sep 5, 2006·Current Biology : CB·Hema Prasad Narra, Howard Ochman
Dec 8, 2006·Genetics·Xavier Didelot, Daniel Falush
Jan 6, 2007·International Journal of Antimicrobial Agents·Katherine M E Turner, Edward J Feil
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ulrich NübelMark Achtman
May 26, 2009·Trends in Microbiology·Michiel Vos
Jan 23, 2010·Science·Simon R HarrisStephen D Bentley

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Citations

May 28, 2011·Biology Direct·Sandeep J JosephTimothy D Read
Jan 30, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marcos Pérez-LosadaKeith A Crandall
Jul 13, 2016·BMC Microbiology·Célio D Santos-JúniorJoana Costa
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Oct 18, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Enze LinYe Feng

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