Impact of Recurrent Ventricular Tachyarrhythmia on Outcome in Japanese Heart Transplant Candidates With a Left Ventricular Assist Device

Circulation Journal : Official Journal of the Japanese Circulation Society
Hidetoshi HattoriNobuhisa Hagiwara

Abstract

Recurrent ventricular tachyarrhythmias (VTA) are "A factor" modifiers in the Interagency Registry for Mechanically Assisted Circulatory Support profile. The effect of recurrent VTA on clinical outcome, however, is controversial. We evaluated the impact of recurrent VTA on outcome in Japanese heart transplant candidates with a left ventricular assist device (LVAD). Methods and Results: Sixty-six adult patients with advanced heart failure who were listed for heart transplantation between January 2005 and October 2017 were enrolled in the study. Recurrent VTA (modifier A status) was defined as a sustained ventricular tachycardia or fibrillation that required implantable cardioverter defibrillator shocks or an external defibrillator more than twice weekly. The primary outcome was death from any cause. The secondary outcomes were the first occurrence of VTA and recurrent VTA after LVAD implantation. Sixteen patients (24%) met the criteria for modifier A status, and 15 patients had an LVAD implanted. During a median follow-up of 1,124 days, 21 of 60 patients with an LVAD died. There was a significantly higher mortality rate in LVAD patients with modifier A status than in those who did not meet the modifier A criteria. On multivariate...Continue Reading

References

Jan 10, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nicholas C DangYoshifumi Naka
Apr 18, 2007·The American Journal of Cardiology·Maninder BediSrinivas Murali
Sep 5, 2008·The New England Journal of Medicine·Jeanne E PooleGust H Bardy
Jun 2, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lynne Warner StevensonJames K Kirklin
Jun 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi Nakatani
Feb 6, 2010·The Journal of Thoracic and Cardiovascular Surgery·Robert L KormosUNKNOWN HeartMate II Clinical Investigators
Feb 25, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daniel J CantillonBruce L Wilkoff
Jan 29, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David FeldmanUNKNOWN International Society for Heart and Lung Transplantation
Jun 20, 2013·Circulation. Arrhythmia and Electrophysiology·Shashima NakaharaEric C Stecker
Jul 23, 2013·Circulation. Arrhythmia and Electrophysiology·Alan D EnriquezSean P Pinney
Aug 31, 2013·Circulation Research·Véronique L Roger
Mar 14, 2014·JACC. Heart Failure·Eugene Braunwald
Jul 28, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Arthur R GaranNir Uriel
Dec 20, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer CowgerChristopher Salerno
Feb 2, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ayhan YorukMehmet K Aktas
Jan 11, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Norihide FukushimaMitsuaki Isobe
Jan 17, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kevin J ClerkinA Reshad Garan
Sep 26, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Takeshi NakataniUNKNOWN J-MACS investigators

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