Impact of Red Wine Consumption on Cardiovascular Health

Current Medicinal Chemistry
Luca LiberaleFederico Carbone

Abstract

The devastating effects of heavy alcohol drinking have been long time recognized. In the last decades, potential benefits of modest red wine drinking were suggested. In European countries in which red wide intake is not negligible (such as France), the association between cholesterol and cardiovascular (CV) risk was less evident, suggesting the action of some protective molecules in red wine or other foods and drinks. This narrative review is based on the material searched for and obtained via PubMed up to May 2016. The search terms we used were: "red wine, cardiovascular, alcohol" in combination with "polyphenols, heart failure, infarction". Epidemiological and mechanistic evidence of a J-shaped relationship between red wine intake and CV risk further supported the "French paradox". Specific components of red wine both in vitro and in animal models were discovered. Polyphenols and especially resveratrol largely contribute to CV prevention mainly through antioxidant properties. They exert beneficial effects on endothelial dysfunction and hypertension, dyslipidemia, metabolic diseases, thus reducing the risk of adverse CV events such as myocardial infarction ischemic stroke and heart failure. Of interest, recent studies pointed ...Continue Reading

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Citations

Jan 10, 2019·Nutrients·Michal BijakJacek Golanski
May 2, 2020·Basic & Clinical Pharmacology & Toxicology·Luca LiberaleThomas F Lüscher
Sep 22, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Shanshan AnQiuyun Liu
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Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ehsan AbediniHossein Samadi Kafil
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlDanut-Eugeniu Mosteanu

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