Impact of Reduced Preincision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study.

Annals of Surgery
Neil R MalhotraMichael Sean Grady

Abstract

Our objective was to determine the impact of total preincision infusion time on surgical site infections (SSIs) and establish an optimal time threshold for subsequent prospective study. SSIs remain a major cause of morbidity. Although regulated, the total time of infusion of preincision antibiotics varies widely. Impact of infusion time on SSI risk is poorly understood. All consecutive patients (n = 46,791) undergoing inpatient surgical intervention were retrospectively enrolled (2014-2015) and monitored for 1 year. Primary outcomes: the presence of SSI infection as predicted by reduced preoperative antibiotic infusion time. preintervention compliance, the impact of a quality improvement algorithm to optimize infusion time compliance. Multivariate logistic regression of the retrospective cohort demonstrated predictors of infection. Receiver-operating characteristic analysis demonstrated the timing threshold predictive of infection. Cost impact of avoidable infections was analyzed. Only 36.1% of patients received preincision infusion of vancomycin in compliance with national and institutional standards (60-120 min). Cephalosporin infusion times were 53 times more likely to be compliant [odds ratio (OR) 53.33, P < 0.001]. Vancomy...Continue Reading

References

Oct 1, 1979·Annals of Internal Medicine·P Newfield, M F Roizen
Oct 1, 1976·Annals of Surgery·H H StoneE J Dawkins
Jan 30, 1992·The New England Journal of Medicine·D C ClassenJ P Burke
Jul 1, 1985·Archives of Surgery·J T DiPiroJ F Sisley
Jul 20, 2001·The Journal of Hospital Infection·P AstagneauUNKNOWN INCISO Network Study Group
May 14, 2003·Journal of the American College of Surgeons·Justin B DimickPamela A Lipsett
Oct 9, 2003·JAMA : the Journal of the American Medical Association·Chunliu Zhan, Marlene R Miller
Sep 30, 2004·Journal of the American College of Surgeons·Justin B DimickDarrell A Campbell
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale W Bratzler, David R Hunt
Jan 23, 2008·Archives of Surgery·Margaret A OlsenVictoria J Fraser
Jun 4, 2008·Annals of Surgery·Walter P WeberAndreas F Widmer
Jun 30, 2009·Annals of Surgery·James P SteinbergUNKNOWN Trial to Reduce Antimicrobial Prophylaxis Errors (TRAPE) Study Group
Dec 14, 2011·Annals of Surgery·John D BirkmeyerJonathan S Skinner
May 23, 2012·The Journal of Thoracic and Cardiovascular Surgery·Colleen G KochEugene H Blackstone
May 29, 2012·Journal of the American College of Surgeons·Elizabeth C WickMartin A Makary
Oct 15, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fatma BozkurtSalih Hoşoglu
May 23, 2014·JAMA Surgery·Marin L SchweizerMary S Vaughan Sarrazin
Jul 16, 2014·The Spine Journal : Official Journal of the North American Spine Society·Andrew J SchoenfeldJohn D Birkmeyer
Jan 24, 2015·Journal of Neurosurgery. Spine·Benjamin D KuhnsThomas E Mroz
Jul 22, 2015·Anesthesia and Analgesia·Robert B SchonbergerRobert S Lagasse
Jan 26, 2017·The British Journal of Surgery·B M GillespieS Kularatna

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