Impact of regadenoson-induced myocardial creep on dynamic Rubidium-82 PET myocardial blood flow quantification

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
S S KoendersJorn A van Dalen

Abstract

Repositioning of the heart during myocardial perfusion imaging (MPI) using Rubidium-82 (Rb-82) PET may occur when using regadenoson. Our aim was to determine the prevalence and the effect of correcting for this myocardial creep on myocardial blood flow (MBF) quantification. We retrospectively included 119 consecutive patients who underwent dynamic rest- and regadenoson-induced stress MPI using Rb-82 PET. The presence of myocardial creep was visually assessed in the dynamic stress PET series by identifying differences between the automatically drawn myocardium contour and the activity. Uncorrected and corrected stress MBFs were compared for the three vascular territories (LAD, LCX, and RCA) and for the whole myocardium. Myocardial creep was observed in 52% of the patients during stress. Mean MBF values decreased after correction in the RCA from 4.0 to 2.7 mL/min/g (P  < 0.001), in the whole myocardium from 2.7 to 2.6 mL/min/g (P  = 0.01), and increased in the LAD from 2.5 to 2.6 mL/min/g (P  = 0.03) and remained comparable in the LCX (P  = 0.3). Myocardial creep is a frequent phenomenon when performing regadenoson-induced stress Rb-82 PET and has a significant impact on MBF values, especially in the RCA territory. As this may ha...Continue Reading

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Citations

Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen
Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Paul C CremerManuel D Cerqueira
Jul 19, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Elia von FeltenRonny R Buechel
Oct 28, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·John R Votaw, René R Sevag Packard
Sep 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ D van Dijk
Sep 29, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yuka OtakiPiotr J Slomka
May 16, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ D van Dijk
Jun 20, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Luca Presotto
May 23, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J D van DijkJ A van Dalen
Aug 8, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Nov 19, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Teresa MannarinoWanda Acampa
Nov 3, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Roberto SciagràUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)
Feb 21, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Mar 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen
Mar 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jonny NordströmMark Lubberink

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