Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task

Psychopharmacology
Madeleine V KingKevin C F Fone

Abstract

Selective 5-ht(6) receptor antagonists like Ro 04-6790 prolong memory in many rodent preclinical paradigms, possibly by blocking tonic 5-HT-evoked GABA release and allowing disinhibition of cortico-limbic glutamatergic and cholinergic neurones. If this is the case, behavioural responses to Ro 04-6790 should be abolished by depletion of endogenous 5-HT, and selective lesions of dorsal raphé (DR) or median raphé (MR) 5-HT pathways would allow the neuroanatomical substrates underlying the cognitive effects of 5-ht(6) receptor antagonists to be elucidated. This study compared the effect of Ro 04-6790 on novel object discrimination (NOD) before and after sham or 5,7-dihydroxytryptamine (5,7-DHT)-induced lesions produced by injection into the lateral ventricles (LV), DR or MR. NOD tests used a 4 h inter-trial interval (ITI) and Ro 04-6790 (10 mg kg(-1) i.p.) was administered 20 min before the familiarization trial. Brain region-specific 5-HT depletion was assessed by high performance liquid chromatography with electrochemical detection (HPLC-ED). Widespread LV or selective MR, but not DR lesions, abolished the ability of Ro 04-6790 to delay natural forgetting. Successful performance of all lesioned rats in subsequent 'drug-free' NOD ...Continue Reading

References

Oct 12, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sinead E ShortallMadeleine V King
Oct 3, 2012·EMBO Molecular Medicine·Julie MeffrePhilippe Marin
Feb 15, 2011·Pharmacology, Biochemistry, and Behavior·Alvin V TerryScott J Webster
Jun 30, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E VenzalaR M Tordera
Jan 10, 2014·Scientific Reports·Farida IslahudinSimon V Avery
Jun 30, 2012·Human Psychopharmacology·Taro KishiNakao Iwata
Mar 5, 2018·Psychopharmacology·Anand M BokareYogendra Nayak

Citations

Sep 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·R AdolfssonB Winblad
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T F FreundK Tóth
Oct 1, 1990·Brain Research. Molecular Brain Research·C BendottiR Samanin
Mar 1, 1988·Journal of the Neurological Sciences·K J ReinikainenP J Riekkinen
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
May 28, 1993·Biochemical and Biophysical Research Communications·M RuatJ C Schwartz
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M RuatJ C Schwartz
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Nov 10, 1998·Biological Psychiatry·S F Leibowitz, J T Alexander
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·H ThomasM Voits
May 23, 2000·Annals of Medicine·M C BuhotL Segu
Oct 31, 2000·Nutrition·M M MeguidF Rossi-Fanelli
Feb 13, 2001·Behavioural Brain Research·Alfredo Meneses
Aug 8, 2001·Neuropharmacology·Marie L WoolleyKevin C F Fone
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lee A DawsonP Li
Nov 10, 2001·Psychopharmacology·Derek Rogers, J J Hagan
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sudabeh Shirazi-SouthallGeorge G Nomikos
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Olivia LehmannJean-Christophe Cassel
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Helen J CassadayCharles A Marsden

Related Concepts

Serotonin 6 receptor
Biochemical Pathway
Serotonin Effect
Salicylhydroxamic acid
Discrimination Learning
Discrimination (Process of Differentiation)
Serotonin
Antagonist Muscle Action
Receptors, Tryptamine
5,7-Dihydroxytryptamine Creatine Sulfate

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.