Impact of remifentanil use on early postoperative outcomes following brain tumor resection or rectal cancer surgery.

Journal of Anesthesia
Kanji UchidaYoshitsugu Yamada

Abstract

Remifentanil, a mu-opioid receptor agonist, has important characteristics for neuroanesthesia, but data about its effects on postoperative recovery and mortality are currently lacking. Using the Japanese Diagnosis Procedure Combination database in 2007, we selected patients who underwent elective brain tumor resection with open craniotomy under general anesthesia using either remifentanil or fentanyl and divided them into two categories: remifentanil patients and non-remifentanil patients. After propensity score matching for potential confounders, we compared the in-hospital mortality and postoperative length of stay (LOS) between the two groups. For comparison, the same endpoints were evaluated for patients underwent rectal cancer surgery under general anesthesia with intraoperative epidural anesthesia. In patients who underwent brain tumor resection (936 pairs), remifentanil patients had significantly lower in-hospital mortality (1.5 % vs. 3.0 %; P = 0.029). Logistic regression analysis revealed that the odds ratio for use of remifentanil for in-hospital mortality was 0.47 (95 % confidence interval, 0.25-0.91; P = 0.025). Remifentanil patients also showed earlier discharge from hospital (median LOS, 17 vs. 19 days; hazard rat...Continue Reading

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Sep 10, 2011·Journal of Anesthesia·Kanji UchidaYoshitsugu Yamada

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Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Jan 24, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·David J CoteLinda S Aglio
Sep 3, 2013·Current Opinion in Anaesthesiology·Federico BilottaGiovanni Rosa
May 31, 2019·Current Opinion in Anaesthesiology·Junichi SaitoDaqing Ma

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