Impact of renal insufficiency on short- and long-term outcomes after cardiac surgery

American Heart Journal
Charmaine E LokJack V Tu

Abstract

Renal insufficiency is highly prevalent in North America and has been established as a nontraditional risk factor for cardiovascular disease. Cardiovascular disease remains the primary cause of mortality in the general population and is often treated with coronary artery bypass surgery (CABG). This population-based study aimed to determine the risk of nondialysis dependent renal insufficiency (RI) on the long-term outcomes of patients who undergo CABG. Prospectively collected data from 26,506 patients were abstracted from the Cardiac Care Network database from 9 revascularization hospitals in Ontario, Canada. Multivariate regression analysis examined associations between preoperative RI and inhospital, 30-day, and 1-year mortality according to 3 levels of serum creatinine: <120 micromol/L (normal), 120 to 180 micromol/L (mild RI), and >180 micromil/L (moderate-severe RI) and 5 levels of creatinine clearance (Cockcroft-Gault): >100 mL/min (normal), 80 to 99 mL/min (mild impairment), 60 to 79 mL/min (mild-moderate impairment), 40 to 59 mL/min (moderate impairment), and <40 mL/min (severe impairment). The overall inhospital, 30-day, and 1-year mortality rates were 1.90%, 2.0%, and 4.5%, respectively. Patients with RI had greater o...Continue Reading

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