Impact of Renal Replacement Therapy in Childhood on Long-Term Socioprofessional Outcomes: A 30-year Follow-Up Study

The Journal of Pediatrics
Lidwien A TjadenJaap W Groothoff

Abstract

To evaluate socioprofessional outcomes after 30 years of renal replacement therapy (RRT) and explore predictors of these outcomes. The cohort comprised all Dutch patients, born before 1979, who started RRT at age <15 years in 1972-1992. Outcomes including family life, educational attainment, and professional life were obtained in 2000 and 2010 in 80 out of 152 survivors. Participants also completed the Course of Life Questionnaire in 2000, which retrospectively assessed the achievement of developmental milestones while growing up. Socioprofessional outcomes in 2010 were compared with the age-matched general population and with outcomes obtained in 2000. Logistic regression analysis was performed to identify determinants of socioprofessional outcomes. Mean age and time on RRT in 2010 were 40.6 years (range 32.1-52.4) and 28.9 years (range 18.1-39.7), respectively. Patients were less likely to be employed (62.5% vs 81.0%) and have children (28.8% vs 64.8%) compared with the age-matched general population. Comorbidities, dialysis, short stature, and fewer milestones on autonomy were associated with adverse outcomes. Compared with 2000, in 2010 more patients lived with a partner (68.8% vs 43.0%), and more patients had completed a h...Continue Reading

References

Jan 1, 1987·Journal of Chronic Diseases·L G Hart, R W Evans
Feb 28, 1985·The New England Journal of Medicine·R W EvansE G Lowrie
Aug 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S J DaviesG I Russell
Jun 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M S MarkellE A Friedman
Apr 14, 1999·Kidney International·G OffnerJ Brodehl
Nov 18, 2000·Pediatric Transplantation·B H BrouhardA Tejani
Feb 19, 2002·Kidney International·Jaap W GroothoffHugo S A Heymans
Mar 22, 2002·Pediatric Transplantation·Erik QvistChrister Holmberg
Oct 23, 2002·Archives of Disease in Childhood·J W GroothoffH S A Heymans
May 21, 2003·Pediatric Transplantation·Märta S EnglundUlla B Berg
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edmund G LowrieDorian Schatell
Jul 29, 2003·Transplantation·Märta EnglundGunnar Tydén
Oct 28, 2003·Transplantation·Sharon M BartoshHans W Sollinger
Apr 17, 2004·Transplantation·Michel BroyerPatrick Niaudet
Jun 25, 2004·The New England Journal of Medicine·Stephen P McDonaldUNKNOWN Australian and New Zealand Paediatric Nephrology Association
Jul 23, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Herwig-Ulf Meier-KriescheBruce Kaplan
Sep 24, 2004·Psycho-oncology·H StamB F Last
Apr 7, 2005·The Journal of Pediatrics·Jaap W GroothoffHugo S A Heymans
Mar 3, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martha Alexandra GrootenhuisJaap W Groothoff
Jul 25, 2006·Transplantation·Sijrike F van der MeiWillem J van Son
Jul 26, 2008·Journal of Medical Internet Research·Victoria Louise FranklinClaudia Pagliari
Aug 2, 2008·Pediatric Transplantation·Helena M E Kärrfelt, Ulla B Berg
Jan 1, 2007·Journal of Psychosocial Oncology·Heleen Maurice-StamBob F Last
Jun 27, 2012·Journal of Medical Internet Research·Sylvia Deidre KauerGeorge Patton
Jan 10, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karlijn J Van StralenUNKNOWN ESPN/ERA-EDTA Registry
Jan 15, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allison TongJonathan C Craig
Mar 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Judith L VogelzangJaap W Groothoff
May 1, 2013·The Journal of Pediatrics·Amira Al-UzriUNKNOWN Chronic Kidney Disease in Children Study Group
Jun 4, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tanjala S PurnellL Ebony Boulware
Oct 5, 2013·Transplantation·Hélène MellerioUNKNOWN French Working Group on the Long-Term Outcome of Transplanted Children
May 20, 2014·The Journal of Pediatrics·Lidwien A TjadenJaap W Groothoff
May 1, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M van HuisJ W Groothoff

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Citations

Mar 13, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Perrine F LimpergMarjolein Peters
Oct 11, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mary Carmelle PhilogeneCozumel S Pruette
Oct 5, 2020·Pediatric Transplantation·Kaushalendra AmatyaElizabeth Steinberg Christofferson
Jul 4, 2018·Pediatric Research·Mina Matsuda-AbediniBruce H Bjornson
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jaap W GroothoffKitty J Jager
Jul 12, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hannah Jacob, Matko Marlais
Nov 21, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sophie LijdsmanJaap W Groothoff

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