Impact of resection margin status on outcome after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma

Head & Neck
Jimmy Y W Chan, William I Wei

Abstract

The purpose of this study was to present the postoperative local tumor control and survival with regard to the different resection margin statuses during salvage nasopharyngectomy. We conducted a whole-organ study of nasopharyngectomy specimens. Between 2005 and 2010, 126 patients underwent maxillary swing nasopharyngectomy. The T classification of the recurrent tumor was: T1, 23.8%; T2, 41.3%; T3, 28.6%; and T4, 6.3%. The chance of clear, close, and involved resection margins at nasopharyngectomy was 44.4%, 31.0%, and 24.6%, respectively. At follow-up, the corresponding risk of local tumor recurrence after surgery was 10.7%, 38.5%, and 67.7%, respectively. The local tumor control was significantly worse in patients with involved margins compared with those with close margins (p = .01), which was, in turn, significantly worse than those with clear margins (p = .04). The primary objective of salvage nasopharyngectomy is to achieve clear resection margins. Close and involved margins result in significantly inferior local tumor control and overall survival. © 2015 Wiley Periodicals, Inc. Head Neck 38: E594-E599, 2016.

References

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Citations

Feb 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·You Quan LiMelvin L K Chua
Nov 9, 2017·The Laryngoscope·Jimmy Yu Wai Chan, William Ignace Wei
Nov 22, 2019·Head & Neck·Philippe GorpheAntoine Moya-Plana
Aug 16, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eugene Hung Chih WongNarayanan Prepageran
Nov 18, 2017·Japanese Journal of Clinical Oncology·Wai Tong NgAnne W M Lee
Mar 27, 2019·Journal of the National Cancer Institute·Quynh Thu LeShakun Malik

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