Impact of resection versus no resection of the primary tumor on survival in patients with colorectal cancer and synchronous unresectable metastases: protocol for a randomized multicenter study (CR4)

International Journal of Colorectal Disease
Sebastiano BiondoSpanish CR4 Group

Abstract

The purpose of this study was to determine whether patients diagnosed with colorectal cancer and synchronous unresectable metastases (stage IV) can benefit from resection of the primary tumor in terms of an improvement in cancer-specific survival. Stage IV colorectal cancer patients are eligible for inclusion in a randomized multicenter study carried out in 22 hospitals throughout Spain. Exclusion criteria are rectal tumors below 12 cm from the anal verge or locally advanced tumors, multiple bone or central nervous system metastases, and history of another primary cancer. The parallel design of the trial includes an arm of systemic chemotherapy alone versus an arm of resection of the primary tumor plus systemic chemotherapy after surgery. The primary endpoint of the study is cancer-specific survival that is assessed with a minimum follow-up of 24 months. Secondary endpoints are postoperative morbidity and mortality associated with resection of the primary tumor, complications and need of surgery in patients treated with systemic chemotherapy only, safety of systemic chemotherapy in both treatment strategies, and quality of life. Confirmation of a survival benefit of surgical resection of the primary tumor in stage IV colorectal...Continue Reading

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Citations

Jul 6, 2019·Journal of Surgical Oncology·Lieve G J LeijssenDavid L Berger
Dec 13, 2019·Japanese Journal of Clinical Oncology·Konosuke MoritaniUNKNOWN Colorectal Cancer Study Group (CCSG) of Japan Clinical Oncology Group (JCOG)
Jun 5, 2018·Annals of Gastroenterological Surgery·Takeru MatsudaYoshihiro Kakeji
Feb 10, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yukihide KanemitsuUNKNOWN JCOG Colorectal Cancer Study Group
Jun 8, 2021·Annals of Gastroenterological Surgery·Yusuke FujitaUNKNOWN Japan Society of Laparoscopic Colorectal Surgery
Jul 14, 2021·Japanese Journal of Clinical Oncology·Tomoyuki HishidaHisao Asamura

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