Impact of resveratrol in the reduction of the harmful effect of diabetes on peri-implant bone repair: bone-related gene expression, counter-torque and micro-CT analysis in rats.

Acta Odontologica Scandinavica
M G CorrêaFabiano Ribeiro Cirano

Abstract

Investigate the impact of resveratrol (RESV) on peri-implant repair and its effect on bone-related markers in rats with induced diabetes mellitus (DM). Ninety rats were divided into: DM + RESV (n = 18); DM + placebo (PLAC) (n = 18); DM + insulin (INS) (n = 18); DM + RESV + INS (n = 18); Non-DM (n = 18). Diabetes was induced by streptozotocin. One screw-shaped titanium implant was inserted in each tibiae of animals. Treatments were administered during 30 days. After, one of the implants was removed for counter-torque and the peri-implant tissue was collected for mRNA quantification of BMP-2, OPN, Runx2, Lrp-5, Osx, β-catenin, Dkk1, OPG, and RANKL by Real-time PCR. The other tibia was submitted to MicroCT analysis to measure: bone volume (BV/TV), trabecular thickness (Tb.Th) and bone-implant contact (BIC). Higher counter-torque values were observed for implant removal in DM + RESV, DM + RESV + INS and Non-DM groups when compared to DM + PLAC (p < .05). Augmented Tb.Th was observed in DM + RESV and Non-DM when compared to DM + PLAC group (p < .05), whereas higher BIC was detected in DM + RESV, DM + RESV + INS and Non-DM animals when compared to DM + PLAC (p < .05). Levels of RANKL were downregulated by the RESV and/or INS therapy,...Continue Reading

References

Aug 1, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Alper AlkanCimen Karasu
May 2, 2009·Journal of Dental Research·T W OatesC A McMahan
May 16, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lu GanKenji Sunagawa
Nov 19, 2011·Journal of Clinical Periodontology·Georgios N Belibasakis, Nagihan Bostanci
Feb 18, 2014·International Journal of Oral and Maxillofacial Surgery·R C CasarinF V Ribeiro
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Jun 27, 2015·International Journal of Oral and Maxillofacial Surgery·A ConteF V Ribeiro
Dec 15, 2015·Journal of Clinical Periodontology·Bettina DannewitzBernadette Pretzl
Jan 20, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Li LuZhu Zhimin
Mar 5, 2016·Clinical Oral Implants Research·Karla de Faria VasconcelosFrab Norberto Bóscolo
Mar 24, 2016·Calcified Tissue International·Marie Juul OrnstrupSteen Bønløkke Pedersen
Mar 24, 2016·Journal of Applied Oral Science : Revista FOB·Suzana Peres PimentelMarcio Zaffalon Casati
Dec 17, 2016·Tissue Engineering. Part B, Reviews·Winston A CamargoJeroen J J P van den Beucken
Mar 28, 2017·Journal of Clinical Periodontology·Alberto MonjeWenche S Borgnakke
May 12, 2017·The International Journal of Oral & Maxillofacial Implants·Caroline Ribeiro SerrãoPoliana Mendes Duarte
Sep 2, 2017·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Danilo Siqueira PinoFernanda Vieira Ribeiro
Oct 7, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Forough SamipoorMojtaba Mehrdad
Apr 2, 2018·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ayse Ozcan-KucukUmit Yolcu
Jun 3, 2018·International Journal of Oral and Maxillofacial Surgery·F R CiranoF V Ribeiro
Jun 30, 2018·DNA and Cell Biology·Aladim Gomes LameiraDenise Carleto Andia
Jul 12, 2018·Journal of Applied Oral Science : Revista FOB·Hasan Ayberk AltugMehmet Kürkçü
Sep 7, 2018·Nature·Yuki IkebuchiHiroshi Suzuki
Nov 8, 2018·Clinical Oral Implants Research·Fernanda Vieira RibeiroMarcio Zaffalon Casati
Dec 12, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Delong WangXin Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.