Impact of reticular pseudodrusen on microperimetry and multifocal electroretinography in intermediate age-related macular degeneration

Investigative Ophthalmology & Visual Science
Zhichao WuChi D Luu

Abstract

To examine the influence of reticular pseudodrusen (RPD) on retinal and visual function in intermediate AMD using multifocal electroretinography (mfERG) and microperimetry. In a prospective cross-sectional study, microperimetry and mfERG testing, followed by color fundus photography, near-infrared reflectance imaging and spectral-domain optical coherence tomography (SD-OCT) scans were performed in 120 eyes from 60 participants with bilateral intermediate AMD. The number of subfields with pigmentary changes and RPD within the central 3-mm diameter of the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid and drusen cube root volume within the central 3-mm diameter was determined. The influence of these pathological features on microperimetry and mfERG in this region were examined. Microperimetric sensitivity was not significantly associated with the presence and extent of RPD (P = 0.068), but with drusen volume and extent of pigmentary changes (P < 0.001 for both). However, the presence and extent of RPD was independently and significantly associated with mfERG implicit time, along with drusen volume and the extent of pigmentary changes (P ≤ 0.023). The mfERG response amplitude was not significantly associated with the p...Continue Reading

Citations

Jan 13, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Shasha YangXing Liu
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Jun 4, 2018·Investigative Ophthalmology & Visual Science·Enrico BorrelliLeonardo Mastropasqua
Mar 19, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Clara RamonJordi Monés
Mar 23, 2019·Investigative Ophthalmology & Visual Science·Adrian ReumuellerAndreas Pollreisz
Oct 10, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Antony J Wightman, Robyn H Guymer
Apr 2, 2020·Investigative Ophthalmology & Visual Science·Susanne G PondorferRobert P Finger
Aug 12, 2020·Investigative Ophthalmology & Visual Science·Marlene SassmannshausenSteffen Schmitz-Valckenberg
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Mar 31, 2021·Acta Ophthalmologica·Thomas M W BuckleyRobert E MacLaren
Feb 1, 2019·Survey of Ophthalmology·Karl G CsakyDaniela Ferrara

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