Impact of Roux-en-Y gastric bypass surgery on appetite, alcohol intake behaviors, and midbrain ghrelin signaling in the rat

Obesity
Sunil SirohiJon F Davis

Abstract

Roux-en-Y gastric bypass (RYGB) surgery reduces appetite and stimulates new onset alcohol misuse; however, the genesis of these behavioral changes is unclear. This study is hypothesized that new onset alcohol intake is a behavioral adaptation that occurs secondary to reduced appetite and correlates with altered central ghrelin signaling. Hedonic high-fat diet (HFD) intake was evaluated prior to the assessment of alcohol intake behaviors in RYGB and control rats. Measurements were also taken of circulating ghrelin and ghrelin receptor (GHSR) regulation of neuronal firing in ventral tegmental area (VTA) dopamine (DA) neurons. RYGB rats displayed reduced HFD intake relative to controls. Sham and RYGB rats consumed more alcohol and preferred lower concentrations of alcohol, whereas only RYGB rats escalated alcohol intake during acute withdrawal. Remarkably, GHSR activity, independent of peripheral ghrelin release, set the tonic firing of VTA DA neurons, a response selectively diminished in RYGB rats. This study indicates that gut manipulations lead to increased alcohol intake, whereas RYGB promotes behaviors that may maintain alcohol misuse. Reductions in hedonic feeding and diminished GHSR control of VTA firing further distinguish...Continue Reading

References

Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M DianaZ L Rossetti
Dec 11, 1999·Alcoholism, Clinical and Experimental Research·M S BrodieS B Appel
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M P MasciaR A Harris
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zachary A RoddWilliam J McBride
Aug 1, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roy A Wise
Oct 25, 2006·The Journal of Clinical Investigation·Alfonso AbizaidTamas L Horvath
Jul 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisabet JerlhagJörgen A Engel
Sep 11, 2009·Alcoholism, Clinical and Experimental Research·Nicholas W GilpinHeather N Richardson
Feb 25, 2010·Endocrinology·Andrew C ShinHans-Rudolf Berthoud
Jun 20, 2012·JAMA : the Journal of the American Medical Association·Wendy C KingSusan Z Yanovski
Sep 15, 2012·Obesity Surgery·Panayotis K ThanosAndras Hajnal
Sep 22, 2012·Gastroenterology·Adam P ChambersRandy J Seeley
Jan 15, 2013·Addiction Biology·Michal SzulcTeresa Bobkiewicz-Kozlowska
Feb 14, 2013·Obesity·James E MitchellSteve Wonderlich
Feb 27, 2013·Obesity Surgery·Jon F DavisStephen C Benoit
Apr 6, 2013·JAMA Surgery·Alexis ConasonAllan Geliebter
May 15, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D SandovalD D D'Alessio
Jan 17, 2014·Alcoholism, Clinical and Experimental Research·Elisabet JerlhagJörgen A Engel
Apr 1, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Christina C WeeGeorge L Blackburn
Jan 15, 2015·Neuroscience·S Liu, S L Borgland
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Shuai LiuStephanie L Borgland

❮ Previous
Next ❯

Citations

Jul 12, 2018·Synapse·John HamiltonPanayotis K Thanos
Aug 8, 2019·Praxis·Paolo M Suter, Ludwig Perger
Nov 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Roxanna Zakeri, Rachel L Batterham
Feb 15, 2020·Alcoholism, Clinical and Experimental Research·George Kunos
Jun 20, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yi ZhangGene-Jack Wang
Aug 15, 2019·Current Psychiatry Reports·Valentina IvezajStephanie Sogg
Nov 11, 2019·Current Psychiatry Reports·Julianna N BrutmanJon F Davis
Jul 16, 2021·Nature Reviews. Endocrinology·Robyn M BrownPriya Sumithran
Oct 7, 2021·Current Psychiatry Reports·Scott G EngelKristine Steffen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.