Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.

PloS One
John WaitumbiColin J Sutherland

Abstract

RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis B surface antigen in a hybrid protein. The RTS,S antigen is formulated with GSK Biologicals' proprietary Adjuvant Systems AS02(A) or AS01(B). A recent trial of the RTS,S/AS02(A) and RTS,S/AS01(B) vaccines evaluated safety, immunogenicity and impact on the development of parasitemia of the two formulations. Parasite isolates from this study were used to determine the molecular impact of RTS,S/AS02(A) and RTS,S/AS01(B) on the multiplicity of infection (MOI) and the csp allelic characteristics of subsequent parasitemias. The distribution of csp sequences and the MOI of the infecting strains were examined at baseline and in break-through infections from vaccinated individuals and from those receiving a non-malarial vaccine. The study was conducted in Kombewa District, western Kenya. Semi-immune adults from the three study arms provided isolates at baseline and during break-through infections. Parasite isolates used for determining MOI and divergence of csp T cell-epitopes were 191 at baseline and 87 from break-through infecti...Continue Reading

References

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Citations

Sep 16, 2011·The New England Journal of Medicine·Mahamadou A TheraChristopher V Plowe
Mar 8, 2013·The Journal of Infectious Diseases·Patrick SawaTeun Bousema
Apr 13, 2012·Nature Reviews. Genetics·Sarah K VolkmanDyann F Wirth
Apr 22, 2011·Expert Review of Vaccines·Nathalie Garçon, Marcelle Van Mechelen
Oct 18, 2015·Vaccine·Amed OuattaraChristopher V Plowe
Jun 15, 2011·Vaccine·Louise von Gersdorff Jørgensen, Kurt Buchmann
Oct 22, 2015·The New England Journal of Medicine·Christopher V Plowe
Oct 7, 2015·Future Microbiology·Selidji T AgnandjiMichael Ramharter
Dec 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amed Ouattara, Matthew B Laurens
Dec 4, 2012·The Journal of Infectious Diseases·Amed OuattaraChristopher V Plowe
Nov 15, 2016·Expert Review of Vaccines·Pascale Vandoolaeghe, Lode Schuerman
Nov 5, 2013·The Journal of the Acoustical Society of America·Melanie WeirichJana Brunner
Sep 24, 2019·Human Vaccines & Immunotherapeutics·Matthew B Laurens
Oct 22, 2015·The New England Journal of Medicine·D E NeafseyD F Wirth
Mar 27, 2020·Frontiers in Immunology·Clarisa Beatriz Palatnik-de-Sousa, Dirlei Nico
Feb 9, 2019·Expert Review of Vaccines·Martha M CooperDenise L Doolan

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Methods Mentioned

BETA
genotyping
blood draws
PCR

Clinical Trials Mentioned

NCT00197054

Software Mentioned

excel

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