Impact of sacubitril-valsartan combination in patients with chronic heart failure and sleep apnoea syndrome: the ENTRESTO-SAS study design.

ESC Heart Failure
Dany JaffuelFrançois Roubille

Abstract

Sleep-disordered breathing (SDB) is a highly prevalent co-morbidity in patients with chronic heart failure (CHF) and can play a detrimental role in the pathophysiology course of CHF. However, the best way to manage SDB in CHF remains a matter of debate. Sacubitril-valsartan has been included in the 2016 European Society of Cardiology guidelines as an alternative to angiotensin-converting enzyme inhibitors to further reduce the risk of progression of CHF, CHF hospitalization, and death in ambulatory patients. Sacubitril and valsartan are good candidates for correcting SDB of CHF patients because their known mechanisms of action are likely to counteract the pathophysiology of SDB in CHF. The ENTRESTO-SAS trial is a 3-month, multicentric, prospective, open-label real-life cohort study. Patients eligible for sacubitril-valsartan treatment (i.e. adults with left ventricular ejection fraction ≤35%, who remain symptomatic despite optimal treatment with an angiotensin-converting enzyme inhibitor, a beta-blocker, and a mineralocorticoid receptor antagonist) will be evaluated before and after 3 months of treatment (nocturnal ventilatory polygraphy, echocardiography, laboratory testing, and quality-of-life and SDB questionnaires). The pri...Continue Reading

References

Apr 18, 2000·Heart·J J McMurray, S Stewart
Feb 15, 2001·Circulation·M Burnier
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Shahrokh Javaheri
Aug 19, 2007·Chest·Caterina B BuccaAlessandro Cicolin
Aug 19, 2007·Heart·Arend Mosterd, Arno W Hoes
Nov 18, 2008·American Journal of Respiratory and Critical Care Medicine·Stefania RedolfiT Douglas Bradley
Jan 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira TamuraJunichi Kadota
Dec 9, 2010·Circulation. Cardiovascular Quality and Outcomes·Shannon M DunlayVéronique L Roger
Jul 28, 2012·Journal of Sleep Research·Gisele MauryRobert Poirrier
Mar 30, 2013·European Journal of Heart Failure·Aldo P MaggioniUNKNOWN Heart Failure Association of the European Society of Cardiology (HFA)
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
Dec 3, 2014·Journal of Cardiac Failure·Wolfram GrimmUlrich Koehler
Jan 13, 2015·Journal of the American College of Cardiology·Maria Rosa CostanzoWilliam T Abraham
Feb 1, 2015·European Heart Journal·Rami KhayatWilliam T Abraham
Dec 10, 2015·American Journal of Respiratory and Critical Care Medicine·T Douglas Bradley, John S Floras
Feb 3, 2016·Chest·Shahrokh JavaheriRami Khayat
Mar 2, 2016·American Journal of Respiratory and Critical Care Medicine·Matthew T Naughton
Dec 7, 2016·The European Respiratory Journal·Winfried RanderathPatrick Levy

❮ Previous
Next ❯

Citations

Oct 21, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E A MedvedevaYu V Sviryaev
Oct 30, 2020·International Journal of Environmental Research and Public Health·Pablo Jorge-SamitierRaúl Juárez-Vela
Jul 7, 2021·Hypertension·Kazuomi Kario, Bryan Williams

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02916160
NCT01807897
NCT02794935
NCT01377987
NCT01041924
NCT02203383
NCT01970423

Software Mentioned

ENTRESTO
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.