PMID: 15338846Sep 2, 2004Paper

Impact of safety warnings on drug utilization: marketplace life span of cisapride and troglitazone

Pharmacotherapy
Julie J WilkinsonPaul S Cady

Abstract

To evaluate the impact of safety alerts on the volume of cisapride and troglitazone usage. Retrospective database analysis. University research center. Idaho Medicaid claims data from January 1994--July 2000. Monthly counts of total and new prescriptions filled for cisapride and troglitazone were analyzed graphically over time as a function of all prescriptions. New prescriptions were defined as those filled by patients who had not received the drug within the previous year. A binomial comparison of the 5 months before and after each safety alert was conducted by Poisson distribution. Overall and new cisapride usage increased after the first alert, which occurred in February 1995 (p<0.05). After the second alert, in September 1995, growth in new prescriptions ended but total prescriptions continued to grow (p<0.05). After the third alert, in June 1998, growth in total use ended and the number of new prescriptions declined (p<0.05). The final two alerts (June 1999 and January 2000) were met with significant declines (p<0.05 for both). Troglitazone was the subject of two alerts in October and December 1997. After these, overall usage increased (p<0.05), whereas the number o new prescriptions decreased (p<0.05). The third alert, i...Continue Reading

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Citations

May 21, 2011·European Journal of Clinical Pharmacology·Hélène ThéophileFrançoise Haramburu
Apr 18, 2013·Nature Reviews. Cardiology·Raymond L Woosley, Klaus Romero
Sep 27, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Keith B HoffmanColin B Erdman
Oct 30, 2012·Journal of the American Medical Informatics Association : JAMIA·Carolyn PetersenBonnie Kaplan
May 22, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Peter G M MolFlora M Haaijer-Ruskamp
Oct 9, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gabriel Sanfélix-GimenoTeresa Barbera
Apr 7, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sigrid PieningPeter G M Mol
Dec 22, 2009·Gaceta sanitaria·Eduardo Carracedo-Martínez, Agustín Pía-Morandeira
Oct 13, 2009·Medicina clínica·Eduardo Carracedo Martínez, Agustín Pía-Morandeira
Apr 17, 2007·Pharmacoepidemiology and Drug Safety·Angela J DeanTreasure McGuire
Nov 25, 2005·British Journal of Clinical Pharmacology·Adrianne FaberLolkje T W de Jong-van den Berg
Jan 12, 2012·Pharmacoepidemiology and Drug Safety·Eduardo Carracedo-MartínezAdolfo Figueiras
Mar 13, 2014·Pharmacoepidemiology and Drug Safety·Inna GridchynaYola Moride
Aug 11, 2015·Clinical Therapeutics·Sara SoaresMaria Teresa Herdeiro
Jun 5, 2016·Fundamental & Clinical Pharmacology·Maria T HerdeiroAdolfo Figueiras
Nov 7, 2017·British Journal of Clinical Pharmacology·Thomas GoedeckeXavier Kurz
Nov 20, 2016·Pharmacoepidemiology and Drug Safety·Isabel Rosich MartíMaria Soler Cera

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