Impact of sarcopenia in patients with advanced non-small cell lung cancer treated with PD-1 inhibitors: A preliminary retrospective study

Scientific Reports
Takayuki ShiroyamaAtsushi Kumanogoh

Abstract

The aim of this study was to investigate the clinical impact of sarcopenia on the efficacy of programmed death (PD)-1 inhibitors. We retrospectively reviewed the medical records of all patients treated with nivolumab or pembrolizumab between January 2016 and September 2018 for previously treated advanced non-small cell lung cancer (NSCLC). The cross-sectional area of the psoas muscle at the level of the third lumbar vertebra on baseline computed tomography was assessed to calculate the psoas muscle index (PMI). Sarcopenia was defined based on PMI cut-off values for Asian adults (6.36 cm2/m2 for males and 3.92 cm2/m2 for females). A total of 42 patients were analysed. The prevalence of sarcopenia was 52.4%. Sarcopenia was significantly associated with poorer progression-free survival (PFS) (median, 2.1 vs. 6.8 months, p = 0.004). Compared to patients with sarcopenia, those without sarcopenia had a higher overall response rate (40.0% vs. 9.1%, p = 0.025) and 1-year PFS rate (38.1% vs. 10.1%). In conclusion, sarcopenia at baseline as determined using computed tomography is a significant predictor of worse outcome in patients with advanced NSCLC receiving PD-1 blockade. Screening for sarcopenia may help identify patients more likel...Continue Reading

References

Oct 17, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marina MourtzakisVickie E Baracos
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra S McAllister, Robert A Weinberg
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Jul 9, 2011·Nature Immunology·E John Wherry
Apr 5, 2012·Nature Reviews. Endocrinology·Bente K Pedersen, Mark A Febbraio
Dec 5, 2012·Nature Reviews. Clinical Oncology·Kenneth FearonVickie Baracos
Jan 2, 2013·Journal of the American Medical Directors Association·Donja M MijnarendsJos M G A Schols
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Eun Young KimYu Mi Jeong
Feb 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shlomit Strulov ShacharTomohiro F Nishijima
Sep 1, 2016·The New England Journal of Medicine·Alejandro Lucia, Manuel Ramírez
Oct 31, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuzo SuzukiYoshihiko Maehara
Dec 8, 2016·The Lancet Oncology·Geoffrey T GibneyMichael B Atkins
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kenji ChamotoTasuku Honjo
Mar 14, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stephen J BagleyCorey J Langer
May 5, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CurrowK C Fearon
Dec 2, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kenichi NishieMasayuki Hanaoka
May 12, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ryota NakamuraToru Terashima

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Citations

May 18, 2019·American Society of Clinical Oncology Educational Book·Rawad Elias, Oreofe Odejide
Aug 8, 2019·Current Opinion in Supportive and Palliative Care·Davide BroccoAntonino Grassandonia
Jul 4, 2019·Journal of Thoracic Imaging·Amelie S TroschelFlorian J Fintelmann
Nov 28, 2019·The Oncologist·Alice AvanciniSara Pilotto
Feb 20, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Anthony J SannicandroKatarzyna Goljanek-Whysall
Feb 7, 2020·Journal of Cancer Research and Clinical Oncology·Kazuki TakadaMasaki Mori
Apr 5, 2020·Cancers·Michael F ColemanStephen D Hursting
Dec 23, 2019·Endocrine·Haruhiko YamazakiKouichi Ito
Sep 25, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yeun-Yoon KimDongil Choi
Jan 17, 2020·Cancers·Ruizhong Wang, Harikrishna Nakshatri
Oct 27, 2020·International Journal of Clinical Oncology·Yasushi MurachiTaroh Satoh
Nov 24, 2020·International Journal of Clinical Oncology·Mikihiro KanoShinya Takahashi
Nov 13, 2020·Current Opinion in Supportive and Palliative Care·Iain Phillips, Samantha Kestenbaum
Feb 25, 2021·Cancer Immunology, Immunotherapy : CII·Yuli Guzman-PradoOndrej Samson
Mar 13, 2020·The Oncologist·Alice AvanciniSara Pilotto
May 11, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kazuki TakadaMasaki Mori
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ersilia NigroAurora Daniele
Dec 4, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laure HirschFrançois Goldwasser
Jun 26, 2021·Pharmacology & Therapeutics·Lysanne DesharnaisDaniela F Quail
Jul 19, 2021·Nutrition·Koichi TakiguchiDaisuke Ichikawa
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jingjing FanZhi-Xiang Xu
Aug 3, 2021·Journal of Cachexia, Sarcopenia and Muscle·Yukinori TakenakaHidenori Inohara
Mar 23, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Benoît RochSébastien Bommart
Oct 1, 2021·Frontiers in Genetics·Fu-Mei HsiehChen-Ching Lin

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