Impact of screening and early detection of impaired fasting glucose tolerance and type 2 diabetes in Canada: a Markov model simulation.

ClinicoEconomics and Outcomes Research : CEOR
Soroush MortazAlaa Badawi

Abstract

Type 2 diabetes mellitus (T2DM) is a major global health problem. An estimated 20%-50% of diabetic subjects in Canada are currently undiagnosed, and around 20%-30% have already developed complications. Screening for high blood glucose levels can identify people with prediabetic conditions and permit introduction of timely and effective prevention. This study examines the benefit of screening for impaired fasting glucose (IFG) and T2DM. If intervention is introduced at this prediabetic stage, it can be most effective in delaying the onset and complications of T2DM. Using a Markov model simulation, we compare the cost-effectiveness of screening for prediabetes (IFG) and T2DM with the strategy of no screening. An initial cohort of normoglycemic, prediabetic, or undiagnosed diabetic adults with one or more T2DM risk factors was used to model the strategies mentioned over a 10-year period. Subjects without known prediabetes or diabetes are screened every 3 years and persons with prediabetes were tested for diabetes on an annual basis. The model weighs the increase in quality-adjusted life-years (QALYs) associated with early detection of prediabetes and earlier diagnosis of T2DM due to lifestyle intervention and early treatment in as...Continue Reading

References

Sep 7, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·E C Goyder, L M Irwig
Dec 28, 2002·Diabetes Care·Saul GenuthUNKNOWN American Diabetes Association
Dec 28, 2002·Diabetes Care·William H HernanUNKNOWN Diabetes Prevention Program Research Group
May 20, 2003·PharmacoEconomics·Maria Raikou, Alistair McGuire
May 6, 2004·Annals of Internal Medicine·Thomas J HoergerMichael Engelgau
Jan 19, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Denice S FeigUNKNOWN Canadian Task Force on Preventive Health Care
Mar 2, 2005·Annals of Internal Medicine·William H HermanUNKNOWN Diabetes Prevention Program Research Group
Aug 19, 2007·Diabetes Care·Thomas J HoergerMichael M Engelgau
Apr 23, 2008·BMJ : British Medical Journal·Clare L GilliesKamlesh Khunti
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Apr 23, 2010·Applied Health Economics and Health Policy·Thilo M Schaufler, Malte Wolff
Jul 1, 2010·Diabetes Care·Ranee ChatterjeeLawrence S Phillips
Jan 1, 2010·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Alaa BadawiMohamed Karmali

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Citations

Nov 8, 2014·Osong Public Health and Research Perspectives·Patrício Fernando Lemes Dos SantosCarlos Kusano Bucalen Ferrari
May 26, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·R S DadwaniN Laiteerapong

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