PMID: 11328220May 1, 2001Paper

Impact of second look laparotomy and secondary cytoreductive surgery at second-look laparotomy in ovarian cancer patients

Acta Obstetricia Et Gynecologica Scandinavica
A Obermair, P Sevelda

Abstract

Currently, no prospective study supports or refutes the value of secondary cytoreductive surgery in patients with ovarian cancer. We therefore reviewed the surgical data of patients who underwent second-look laparotomy (SLL) with or without secondary cytoreductive surgery at our department. Analysis is based on the data of 179 patients who had FIGO stage II (suboptimally staged), stage III or IV ovarian cancer, who received a platinum-based first-line chemotherapy, who were clinically considered to be tumor-free or had at least a clinically partial response to first-line chemotherapy, and who underwent SLL. In patients with macroscopic tumor the diagnostic SLL was followed by a secondary cytoreductive surgery in order to remove as much tumor as possible. Patients with a positive SLL were given second-line chemotherapy. Survival from SLL until death was considered the primary statistical endpoint. In 78 out of 179 (43.5%) a negative SLL could be confirmed pathologically. Patients with negative findings, with microscopic, and macroscopic disease at SLL had a median survival of 66.6, 57.2, and 19.0 months, respectively (p=0.0001). In patients who underwent a secondary cytoreductive operation and in whom residual tumor was none, le...Continue Reading

References

Nov 15, 1984·Cancer·S E VoglE Greenwald

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Citations

Nov 3, 2012·ISRN Obstetrics and Gynecology·Tarak DamakKhaled Rahal
Dec 17, 2003·Gynecologic Oncology·Sean C DowdyKarl C Podratz
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GadducciE Sartori
Dec 1, 2007·Journal of Surgical Oncology·Ali AyhanKunter Yuce

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