Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: functional assessment.

American Journal of Physiology. Renal Physiology
Hannah RuettenChad M Vezina

Abstract

Laboratory mice are used to identify causes of urinary dysfunction including prostate-related mechanisms of lower urinary tract symptoms. Effective use of mice for this purpose requires a clear understanding of molecular, cellular, anatomic, and endocrine contributions to voiding function. Whether the prostate influences baseline voiding function has not been specifically evaluated, in part because most methods that alter prostate mass also change circulating testosterone concentrations. We performed void spot assay and cystometry to establish a multiparameter "baseline" of voiding function in intact male and female 9-wk-old (adult) C57BL/6J mice. We then compared voiding function in intact male mice to that of castrated male mice, male (and female) mice treated with the steroid 5α-reductase inhibitor finasteride, or male mice harboring alleles (Pbsn4cre/+; R26RDta/+) that significantly reduce prostate lobe mass by depleting prostatic luminal epithelial cells. We evaluated aging-related changes in male urinary voiding. We also treated intact male, castrate male, and female mice with exogenous testosterone to determine the influence of androgen on voiding function. The three methods used to reduce prostate mass (castration, fina...Continue Reading

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Citations

Jan 7, 2020·American Journal of Physiology. Renal Physiology·Hannah RuettenChad M Vezina
Jun 15, 2021·American Journal of Physiology. Renal Physiology·Lisa L AblerChad M Vezina
Aug 3, 2021·Physiological Reports·Hannah M RuettenChad M Vezina

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Methods Mentioned

BETA
urine collection

Software Mentioned

VisonWorksLS
Graph Pad Prism
Void Whizzard
PowerLab
Graphpad
UVP

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