Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Hirofumi TomitaKen Okumura

Abstract

Female sex is a risk factor for thromboembolic events in Caucasian, but not in Japanese, patients with nonvalvular atrial fibrillation. However, it remains unclear whether the female sex is also a risk factor for severe stroke and unfavorable functional outcome in patients with cardioembolic (CE) stroke. Three hundred fifty-five consecutive patients with CE stroke within 48 hours after onset and with a modified Rankin Scale (mRS) score of 1 or lower before onset were studied. We compared basic characteristics, stroke severity, and functional outcome between female (n = 157) and male (n = 198) patients. The mean age was higher in female than in male patients (80 ± 8 versus 75 ± 9 years, P < .00001). The congestive heart failure, hypertension, age [≥ 75 years], diabetes, stroke/transient ischemic attack [TIA] (CHADS2) score before onset was similar between the two groups (median, 3 [2-4] in both groups). Stroke severity on admission, assessed by the National Institutes of Health Stroke Scale (NIHSS), was higher in female than in male patients (13 [5-20] versus 8 [3-16], P = .0009). Functional outcome at discharge, assessed by mRS, was unfavorable in female than in male patients (3 [1-5] versus 2 [1-4], P = .005). An mRS score of ...Continue Reading

References

Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Jaume RoquerMeritxell Gomis
Jan 2, 2009·Stroke; a Journal of Cerebral Circulation·Marie ErikssonBirgitta Stegmayr
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chad SiegelLouise D McCullough
Dec 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yingfang TianFrank R Sharp
Jan 28, 2014·The American Journal of Cardiology·Hiroshi InoueUNKNOWN J-RHYTHM Registry Investigators
Jan 1, 2015·Stroke; a Journal of Cerebral Circulation·Fumi IrieUNKNOWN FSR Investigators

❮ Previous
Next ❯

Citations

Jun 6, 2016·Journal of cardiology·Natasha A KassimSamir Saba
Jun 4, 2016·Geriatrics & Gerontology International·Koji TanakaHiroyuki Murai
Apr 9, 2019·Journal of the American Heart Association·Linn Arvidsson StrømnesInger Ariansen
Jul 2, 2019·International Journal of Language & Communication Disorders·Saryu SharmaCharles Ellis
Aug 4, 2018·Korean Circulation Journal·Yan Guang LiGregory Yh Lip
Sep 5, 2021·The Journal of Clinical Endocrinology and Metabolism·Laura PotassoMirjam Christ-Crain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Naoki SajiKoichi Yokono
The Journal of Clinical Hypertension
Konstantinos TziomalosApostolos I Hatzitolios
© 2021 Meta ULC. All rights reserved