PMID: 33221733Nov 23, 2020Paper

Impact of Sex on Outcomes Among Patients With Cardiac Allograft Vasculopathy Who Undergo Percutaneous Coronary Intervention.

The Journal of Invasive Cardiology
Michael S LeeRichard Shlofmitz

Abstract

Orthotopic heart transplantation (OHT) is a reasonable treatment strategy for patients with endstage heart failure. Percutaneous coronary intervention (PCI) can be performed to treat cardiac allograft vasculopathy (CAV). We sought to examine sex-based differences and outcomes in patients undergoing PCI for CAV. This was a single- center, retrospective study of consecutive patients undergoing PCI for CAV from July 1993 to July 2017. The primary outcome was a composite of death, myocardial infarction (MI), target-vessel revascularization (TVR), or repeat OHT. A total of 140 patients (39% women) who underwent PCI for CAV were studied over a median follow-up of 3.9 years. Women were more likely to be younger and had less hypertension, with a trend toward less diabetes and higher ejection fractions. No significant differences in the primary composite outcome were noted between women and men (hazard ratio, 1.16; 95% confidence interval, 0.76-1.76; P=.49), as well as the individual outcomes of death, MI, or TVR (P>.05 for all). Women were more likely to undergo repeat OHT than men (hazard ratio, 2.93; 95% confidence interval, 1.48-5.81; P<.01). After covariate adjustment, female sex and younger age were independently associated with r...Continue Reading

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