Impact of Sex on the Outcome of Isolated Aortic Valve Replacement and the Role of Different Preoperative Profiles

Journal of Cardiothoracic and Vascular Anesthesia
Joost F Ter WoorstMohamed A Soliman-Hamad

Abstract

The aim of this study was to compare the patient profiles and outcomes of men and women undergoing isolated aortic valve replacement. Patient data were analyzed retrospectively. This single-center study was performed at Catharina Hospital in Eindhoven, the Netherlands. The study comprised 2,362 patients, of whom 1,040 (44%) were women and 1,322 were men (56%). Isolated aortic valve replacement was performed between January 1998 and December 2016. The mean follow-up was 8.3 ± 5.1 years. Women were relatively older (69.9 years v 64.6 years; p < 0.001); more of them were underweight, obese, and diabetic; and they had lower hemoglobin values and worse renal function than did men. However, fewer women than men experienced chronic obstructive pulmonary disease, aortic regurgitation, left ventricular dysfunction, and endocarditis. Early mortality did not differ significantly between men and women (p = 0.238). Overall survival was worse in women (p < 0.001). After correction for potential risk factors, female sex was not associated with worse survival. During the study period, the mean age of patients undergoing aortic valve replacement increased. In addition, the mean age at the time of death increased, following the trend of national...Continue Reading

Citations

Feb 17, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ka Yan LamAlbert H M van Straten
May 24, 2021·European Heart Journal·David Bienjonetti-BoudreauMarie-Annick Clavel

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