Impact of short-course therapy on tuberculosis drug resistance in South-West Burkina Faso

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
S LedruJ P Chiron

Abstract

The Regional Tuberculosis Centre and the Muraz Centre in Bobo-Dioulasso, Burkina Faso. To observe the trend of primary drug resistance in pulmonary tuberculosis patients 5 years into a short-course treatment programme and to assess the possible implementation of a further programme. Bacteriological study of stains isolated from all newly diagnosed tuberculosis patients (n = 300), all relapse cases (n = 20) and all failure cases (n = 58) from the Houet province, during the period from April 1992 to April 1994. Human immunodeficiency virus (HIV) serostatus was determined for the first 119 patients included in the study. Mycobacterium tuberculosis was the predominant species as shown by 75.1% of the isolates; next was M. africanum, then atypical mycobacteria and finally M. bovis, representing 18.4%, 6.5% and 0.4% of the isolates respectively. Primary resistance (excluding atypical strains) was as follows: isoniazid 7.6%, ethambutol 1.0%, rifampicin 2.5%, and streptomycin 12.4%; 33.6% of the patients tested for HIV were HIV positive. There was no relationship between HIV serostatus and the identity of strains or drug resistance. However, negative acid-fast bacilli smear microscopy with positive culture was significantly more freque...Continue Reading

References

Dec 1, 1989·Tubercle·T S van der WerfB van Klingeren
Jun 1, 1993·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A M ElliottK P McAdam
Dec 1, 1995·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G CarpelsF Portaels

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Citations

Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P SonnenbergP Godfrey-Faussett
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