Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies

Environment International
Karin van VeldhovenPaolo Vineis

Abstract

Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Levels of five and four pollutants were measured, respectively, using personal exposure monitoring devices. Serum samples were used for metabolomic profiling. The association between TRAP and levels of each metabolic feature was assessed. All pollutant levels were significantly higher at the high pollution sites. 29 and 77 metabolic features were associated with at least one pollutant in the Oxford Street II and TAPAS II studies, respectively, which related to 17 and 30 metabolic compounds. Little overlap was observed across pollutants for metabolic features, suggesting that different pollutants may affect levels of different metabolic features. After observing the annotated compounds, the main pathway suggested in Oxford Street II i...Continue Reading

Citations

Aug 14, 2019·Reviews on Environmental Health·Pan DengBernhard Hennig
Jul 18, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·B M R AppenzellerL Aguilar
Aug 10, 2020·Current Environmental Health Reports·Kosuke InoueBeate Ritz
Sep 21, 2020·Metabolomics : Official Journal of the Metabolomic Society·Yiqing WangPenny Gordon-Larsen
Jan 10, 2021·Current Environmental Health Reports·Lan JinYawei Zhang
Jul 4, 2020·Environment International·Paolo VineisSonia Dagnino
Jan 9, 2021·Environmental Health : a Global Access Science Source·Feiby L NassanJoel D Schwartz
Feb 28, 2021·Environment International·Feiby L NassanJoel D Schwartz
Nov 21, 2020·Toxicology and Applied Pharmacology·Samantha J SnowUrmila P Kodavanti

Methods Mentioned

BETA
light scattering

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