Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes

Nature Communications
Claudia RückertGregory D Ebel

Abstract

The recent emergence of both chikungunya and Zika viruses in the Americas has significantly expanded their distribution and has thus increased the possibility that individuals may become infected by more than one Aedes aegypti-borne virus at a time. Recent clinical data support an increase in the frequency of coinfection in human patients, raising the likelihood that mosquitoes could be exposed to multiple arboviruses during one feeding episode. The impact of coinfection on the ability of relevant vector species to transmit any of these viruses (that is, their vector competence) has not been determined. Thus, we here expose Ae. aegypti mosquitoes to chikungunya, dengue-2 or Zika viruses, both individually and as double and triple infections. Our results show that these mosquitoes can be infected with and can transmit all combinations of these viruses simultaneously. Importantly, infection, dissemination and transmission rates in mosquitoes are only mildly affected by coinfection.

References

Feb 1, 2007·BMC Microbiology·Ma Isabel SalazarBarry J Beaty
Jul 3, 2007·PLoS Pathogens·Marion SourisseauOlivier Schwartz
Jul 5, 2008·Emerging Infectious Diseases·Mahery RatsitorahinaJean Louis Soares
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Jul 13, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A PierroV Sambri
Jun 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mélanie CaronEric Maurice Leroy
Jun 22, 2012·PLoS Neglected Tropical Diseases·Diawo DialloMawlouth Diallo
Dec 12, 2012·PloS One·Miranda Chan, Michael A Johansson
Jan 15, 2014·PLoS Neglected Tropical Diseases·Oumar FayeAmadou Alpha Sall
Feb 12, 2014·PLoS Neglected Tropical Diseases·Gilda GrardEric Maurice Leroy
Apr 12, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·R OmarjeeI Leparc-Goffart
Jul 31, 2014·Emerging Infectious Diseases·Robert S Lanciotti, Anne Marie Valadere
Jan 28, 2015·Emerging Infectious Diseases·Myrielle Dupont-RouzeyrolAnn-Claire Gourinat
Feb 13, 2015·Virusdisease·Claudia RückertRennos Fragkoudis
Mar 17, 2015·PLoS Neglected Tropical Diseases·Nathan D GrubaughDoug E Brackney
Dec 15, 2015·PLoS Neglected Tropical Diseases·Farah Z Vera-MaloofWilliam C Black Iv
Jan 13, 2016·Journal of Infection and Public Health·Wilmer E Villamil-GómezAlfonso J Rodriguez-Morales
Jan 26, 2016·Vector Borne and Zoonotic Diseases·Emiliana Pereira Abrao, Benedito Antônio Lopes da Fonseca
Mar 5, 2016·BMC Infectious Diseases·Luis Furuya-KanamoriLaith Yakob
Mar 19, 2016·Vector Borne and Zoonotic Diseases·Pedro F C Vasconcelos, Charles H Calisher
Apr 19, 2016·Emerging Infectious Diseases·Robert S LanciottiLeticia Del Carmen Castillo Signor
Jul 13, 2016·The American Journal of Tropical Medicine and Hygiene·Hector ZambranoBenjamin A Pinsky
Oct 26, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wilmer E Villamil-GómezDidier Musso
Aug 27, 2016·Nature Microbiology·Jianying LiuGong Cheng
Sep 1, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesse J WaggonerBenjamin A Pinsky
Oct 25, 2016·Current Opinion in Virology·Fadila Amraoui, Anna-Bella Failloux
Oct 27, 2016·PLoS Neglected Tropical Diseases·James Weger-LucarelliGregory D Ebel
Jan 13, 2017·PLoS Neglected Tropical Diseases·Natapong JupatanakulGeorge Dimopoulos

❮ Previous
Next ❯

Citations

Mar 8, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Açucena Veleh RivasDaniela Dib Gonçalves
Jan 25, 2018·The American Journal of Tropical Medicine and Hygiene·Mya Myat Ngwe TunKouichi Morita
Mar 10, 2018·Viruses·William H PalmerRonald P van Rij
Feb 15, 2018·Viruses·Elisa X Y LimLara J Herrero
Apr 17, 2018·The Journal of Infectious Diseases·Barbara Aparecida ChavesNágila Francinete Costa Secundino
Nov 7, 2017·PLoS Neglected Tropical Diseases·Tereza MagalhaesErnesto T A Marques
Nov 19, 2017·EcoHealth·Sarah J ThompsonAndrew M Ramey
Aug 4, 2018·Reviews in Medical Virology·Vivian I Avelino-Silva, Esper G Kallas
Nov 16, 2018·PloS One·Kurt Steinwascher
Jan 23, 2019·PLoS Biology·Chantal B F VogelsNathan D Grubaugh
Jan 10, 2019·Tropical Medicine & International Health : TM & IH·Freddy PerezJose Luis San Martin
Mar 14, 2019·Expert Reviews in Molecular Medicine·Pa WuGong Cheng
Jun 13, 2019·PLoS Neglected Tropical Diseases·Melisa Berenice BonicaSilvana Levis
Jan 15, 2020·Bulletin of Mathematical Biology·Omomayowa Olawoyin, Christopher Kribs
Feb 12, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mya Myat Ngwe TunKouichi Morita
May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Alexis RobisonGregory D Ebel
Aug 4, 2020·Tropical Medicine & International Health : TM & IH·André de Souza LeandroWagner Antonio Chiba de Castro
Jun 13, 2018·Genes·Raphaëlle KlittingXavier de Lamballerie
Aug 23, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Thaísa Regina Rocha LopesJosé Valter Joaquim Silva Júnior
Nov 14, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V C ManieroS V Cardozo
Jun 14, 2020·BMC Public Health·Iasmyn Dayanne Santos do NascimentoJosé Valter Joaquim Silva Júnior
Apr 26, 2018·PLoS Neglected Tropical Diseases·João Ricardo Nickenig VissociCatherine Staton
May 21, 2019·PLoS Neglected Tropical Diseases·Eric P CaragataLuciano A Moreira
Nov 7, 2019·Bulletin of Entomological Research·A Laura Flores-VillegasAlex Córdoba-Aguilar
Dec 18, 2019·Nature Communications·Rebecca K BorcheringDerek A T Cummings
Jun 8, 2018·Frontiers in Microbiology·Hong-Wai ThamMiaw-Fang Chew

❮ Previous
Next ❯

Datasets Mentioned

BETA
KJ451624
AY449677
KU501215

Methods Mentioned

BETA
PCR
fluorescence microscopy
dissections

Software Mentioned

GraphPad Prism

Related Concepts