Impact of soluble HLA-G levels and endometrial NK cells in uterine flushing samples from primary and secondary unexplained infertile women

International Journal of Molecular Sciences
Roberta RizzoRoberto Marci

Abstract

The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56+KIR2DL4+ (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56+KIR2DL4+ (e)NK cell percentages.

Associated Clinical Trials

Jul 10, 2018·Giuseppe Lo Monte

References

Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
May 20, 2008·Autoimmunity Reviews·Roberto PerriconeYehuda Shoenfeld
Aug 6, 2009·Human Immunology·Roberta RizzoOlavio R Baricordi
Apr 30, 2011·Clinical Chemistry·Alvaro GonzalezJosé Ignacio Echeveste
Aug 31, 2012·Inflammation & Allergy Drug Targets·Roberta RizzoEnrico Fainardi
Apr 17, 2014·American Journal of Reproductive Immunology : AJRI·Mette DahlThomas Vauvert F Hviid

❮ Previous
Next ❯

Citations

Jan 27, 2016·Human Immunology·Inès ZidiDaria Bortolotti
Sep 22, 2016·Journal of Immunology Research·Fabio MorandiVito Pistoia
Apr 26, 2017·American Journal of Reproductive Immunology : AJRI·Louise KofodThomas Vauvert F Hviid
Jul 25, 2019·American Journal of Reproductive Immunology : AJRI·Daria BortolottiRoberta Rizzo
Dec 28, 2019·Microorganisms·Elisabetta CaselliClodoveo Ferri
Jul 9, 2020·Archives of Gynecology and Obstetrics·Xiang HongBei Wang
Apr 24, 2019·Advanced Pharmaceutical Bulletin·Elnaz MosaferiBehzad Baradaran
Dec 15, 2019·Journal of Reproductive Immunology·Line Lynge NilssonThomas Vauvert F Hviid

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Flow Cytometry

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.