Impact of specific coronary lesions on regional ischemia at single photon emission computed tomography

Journal of Cardiovascular Medicine
Francesco NudiAmi E Iskandrian

Abstract

Prior studies using stress myocardial perfusion imaging (MPI), which examined the association between obstructive epicardial coronary disease and presence of myocardial ischemia did not provide a detailed assessment on a regional level. We examined this relationship in a large population of patients in whom the coronary anatomy was defined by invasive coronary angiography. We retrospectively extracted details on individuals undergoing MPI with single photon emission computed tomography (SPECT) who had coronary angiography within 12 months. A 17-segment model for native coronary anatomy and a 7-region model for myocardial perfusion were used with a dedicated matching algorithm. A total of 2564 patients were included, yielding a total of 6279 stenoses matched with 17 948 myocardial regions. From such a cohort, 151 (5.9%) patients had normal perfusion, 1878 (73.2%) had myocardial ischemia (reversible defects), 260 (10.1%) had myocardial necrosis (scar or fixed defects), and 275 (10.7%) had ischemia and necrosis. At per-patient analysis, significant angiographic disease was more common in the ischemic group (prevalence between 69.6 and 80.0%) than other groups. At per-region analysis, abnormal perfusion in the coronary-specific reg...Continue Reading

References

Jan 1, 1981·Circulation·J T Shepherd
Apr 8, 2003·Journal of the American College of Cardiology·Giuseppe G L Biondi-ZoccaiLuigi M Biasucci
Mar 14, 2007·Circulation·Paolo Angelini
Nov 24, 2007·American Heart Journal·Alexander GoldbergUNKNOWN Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators
Jul 25, 2009·Journal of Interventional Cardiology·Paolo GarronePierfrancesco Agostoni
Jun 4, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francesco NudiOrazio Schillaci
Jan 18, 2015·Journal of cardiology·Francesco NudiGiuseppe Biondi-Zoccai
Apr 2, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francesco NudiGiuseppe Biondi-Zoccai
Aug 8, 2015·Coronary Artery Disease·Jerrett K Lau, Andy S C Yong
Nov 13, 2015·The New England Journal of Medicine·Steven P SedlisUNKNOWN COURAGE Trial Investigators
Nov 26, 2015·Journal of Cardiovascular Medicine·Marco CanepaGianmario Sambuceti
Dec 15, 2015·Journal of Cardiovascular Medicine·Chiara AnchisiElena Grossini
Mar 27, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken Dilsizian
Jul 30, 2016·Journal of Cardiovascular Medicine·Hemang B PanchalTimir K Paul
Jan 13, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francesco NudiGiuseppe Biondi-Zoccai
Mar 3, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francesco Nudi, Giuseppe Biondi-Zoccai
Aug 24, 2017·Journal of Cardiovascular Medicine·Dorota OchijewiczJanusz Kochman
Nov 8, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·James R J FoleyJohn P Greenwood

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