Impact of squalene-based adjuvanted influenza vaccination on graft outcome in kidney transplant recipients

Transplant Infectious Disease : an Official Journal of the Transplantation Society
M Fernández-RuizJ M Aguado

Abstract

Safety concerns have been raised about the use of adjuvanted vaccines after kidney transplantation. We retrospectively analyzed 65 kidney transplant (KT) recipients who received ≥1 dose of influenza vaccine (pandemic or seasonal) during the 2009-2010 campaign. Participants were classified into 2 groups: those who received a squalene-based AS03- or MF59-adjuvanted vaccine ("adjuvanted vaccination" [AV] group, n = 37) and those who exclusively received non-adjuvanted vaccines ("non-adjuvanted vaccination" [NAV] group, n = 28). Primary outcomes included occurrence of biopsy-proven acute graft rejection (BPAR) and graft function at months 6 and 12 after vaccination. Patients were followed up until graft loss, death, or October 2010. Four episodes of BPAR occurred during post-vaccination follow-up, with no differences between the AV and NAV groups, in terms of cumulative incidence (5.4% vs. 7.1%, respectively; P = 0.581), incidence rate (0.22 vs. 0.18 episodes per 1000 transplant-days; P = 0.950), or occurrence of severe episodes (T-cell-mediated BPAR of grade ≥2a) (2.7% vs. 3.6%; P = 0.680). No between-group differences were seen in graft function after vaccination. Adjuvanted influenza vaccination in KT recipients seems to be safe...Continue Reading

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Citations

Jun 6, 2015·Expert Opinion on Drug Safety·Nicola PrincipiUNKNOWN ESCMID Vaccine Study Group (EVASG)
May 14, 2016·Expert Review of Vaccines·Paul LoubetOdile Launay
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Oct 15, 2019·Clinics and Research in Hepatology and Gastroenterology·Florent ValourOdile Launay
May 25, 2021·Current Treatment Options in Infectious Diseases·Tara M Babu, Camille N Kotton

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