Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS

JACC. Cardiovascular Imaging
Kousuke HattoriJagat Narula

Abstract

The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics. Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months. Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.03...Continue Reading

References

Feb 19, 2002·Journal of the American College of Cardiology·Ik-Kyung JangGuillermo J Tearney
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Feb 21, 2006·Journal of the American College of Cardiology·Keiji SanoHisayoshi Fujiwara
Apr 18, 2006·The American Journal of Cardiology·Teruyoshi KumeKiyoshi Yoshida
Apr 25, 2006·Journal of the American College of Cardiology
Apr 25, 2006·Journal of the American College of Cardiology·Debra StamperMark Brezinski
Apr 10, 2007·Journal of the American College of Cardiology·Nobuhiro TaharaTsutomu Imaizumi
Sep 4, 2007·European Heart Journal·Gastón A Rodriguez-GranilloUNKNOWN EUROPA/PERSPECTIVE Investigators
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Sep 9, 2010·European Heart Journal·Hector M Garcia-GarciaPatrick W Serruys

❮ Previous
Next ❯

Citations

Aug 29, 2013·Current Atherosclerosis Reports·Eric A Osborn, Farouc A Jaffer
Aug 21, 2013·Lancet·Stephan WindeckerMichael S Marber
May 24, 2013·The New England Journal of Medicine·Peter Libby
Sep 4, 2012·BMC Cardiovascular Disorders·Jinwei TianBo Yu
Apr 2, 2014·The International Journal of Cardiovascular Imaging·Hye Rin KimCharles S White
May 24, 2014·Nature Reviews. Drug Discovery·Bronwyn A KingwellNorman E Miller
Apr 29, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tomasz RolederAnnapoorna S Kini
Feb 18, 2016·Current Cardiology Reports·Jonathan A BattyVijay Kunadian
Dec 3, 2014·Journal of the American College of Cardiology·Pedro R Moreno
Dec 3, 2014·International Journal of Cardiology·Rong BingHarry C Lowe
Feb 14, 2015·JACC. Cardiovascular Imaging·Hannah SinclairVijay Kunadian
Jun 20, 2015·Trends in Cardiovascular Medicine·Konstantinos C KoskinasLorenz Räber
Aug 14, 2012·Current Opinion in Pharmacology·Farhad Abtahian, Ik-Kyung Jang
Mar 10, 2016·Clinical Radiology·P D AdamsonD E Newby
May 15, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiromu YamazakiMasataka Sata
Sep 21, 2015·Atherosclerosis·Sung Gyun AhnHabib Samady
Apr 16, 2016·Trends in Cardiovascular Medicine·Csilla CelengPál Maurovich-Horvat
Jun 21, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Taishi YonetsuIk-Kyung Jang
Oct 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sebastian ReithMathias Burgmaier
Aug 27, 2015·Journal of Internal Medicine·I GonçalvesG Pasterkamp
Jul 25, 2015·Journal of the American College of Cardiology·Eugene Braunwald
Jul 26, 2014·Journal of the American College of Cardiology·Paul Schoenhagen, D Geoffrey Vince
Mar 4, 2014·Journal of the American College of Cardiology·Matthew I TomeyJason C Kovacic
Aug 7, 2013·Journal of the American College of Cardiology·Javier SanzValentin Fuster
Mar 8, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Han-lu LvDeng-feng Geng
Feb 14, 2013·Current Opinion in Pharmacology·Andrea BabelovaRalf P Brandes
Dec 18, 2013·JACC. Cardiovascular Imaging·Pedro R Moreno
Feb 22, 2012·JACC. Cardiovascular Imaging·Pedro R Moreno, Annapoorna Kini
Oct 19, 2013·JACC. Cardiovascular Imaging·Nobuhiro TaharaTsutomu Imaizumi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.