Impact of surgical methodology on the complication rate and functional outcome of patients with a single brain metastasis

Journal of Neurosurgery
Akash J PatelR Sawaya

Abstract

OBJECT Brain metastases are the most common intracranial neoplasms and are on the increase. As radiation side effects are increasingly better understood, more patients are being treated with surgery alone with varying outcomes. The authors previously reported that en bloc resection of a single brain metastasis was associated with decreased incidences of leptomeningeal disease and local recurrence compared with piecemeal resection. However, en bloc resection is often feared to cause an increased incidence of postoperative complications. This study aimed to answer this question. METHODS The authors reviewed data from patients with a previously untreated single brain metastasis, who were treated with resection at The University of Texas M.D. Anderson Cancer Center (1993-2012). Data related to the patient, tumor, and methods of resection were obtained. Discharge Karnofsky Performance Scale (KPS) scores and 30-day postoperative complications were noted. Complications were considered major when they persisted for longer than 30 days, resulted in hospitalization or prolongation of hospital stay, required aggressive treatment, and/or were life threatening. RESULTS During the study period, 1033 eligible patients were identified. The med...Continue Reading

References

Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L GasparR Byhardt
Apr 29, 1998·Journal of Neurology·C J Vecht
Nov 11, 1998·JAMA : the Journal of the American Medical Association·R A PatchellB Young
Feb 9, 1999·Plastic and Reconstructive Surgery·B SinghJ P Shah
Mar 27, 2001·Journal of Neuro-oncology·M T GiordanaA Boghi
Sep 23, 2003·The Journal of Urology·Surena F MatinInderbir S Gill
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jill S Barnholtz-SloanRaymond E Sawaya
Apr 19, 2005·The Surgical Clinics of North America·Fred G Barker
Jul 20, 2005·Archives of Otolaryngology--head & Neck Surgery·Marina BorukGady Har-El
Feb 14, 2006·Head & Neck·Dirk R BuitelaarJohannes M Huitink
Sep 27, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Carsten NiederMichael Molls
Dec 17, 2008·Journal of Neurosurgery·Heon YooSeung Hoon Lee
Dec 29, 2009·Journal of Neurosurgery·Akash J PatelRaymond Sawaya
Sep 8, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Prashant SukharamwalaPeter DeVito
Feb 28, 2013·Journal of Neuro-oncology·Meriç SengözNecmettin Pamir
Apr 16, 2013·International Journal of Radiation Oncology, Biology, Physics·Delphine AntoniGeorges Noël

❮ Previous
Next ❯

Citations

Feb 10, 2016·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A PerrakisG Schackert
Jul 10, 2016·Neurosurgical Review·Marcel A KampMichael Sabel
Oct 2, 2017·Clinical & Experimental Metastasis·Sherise D FergusonRaymond Sawaya
Jun 30, 2018·Future Oncology·Riccardo SoffiettiRoberta Rudà
Sep 29, 2018·Journal of Neurosurgery·Andrew J Fabiano
Aug 25, 2018·Current Opinion in Oncology·Carmine M CarapellaPiero Andrea Oppido
Feb 14, 2019·Expert Review of Anticancer Therapy·Elise F NassifYoulia M Kirova
Jul 5, 2019·Current Oncology Reports·Cristian UdovicichNeda Haghighi
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Nancy U LinRiccardo Soffietti
May 17, 2019·Scientific Reports·Christopher Munoz-BendixMarcel A Kamp
Oct 18, 2016·Current Opinion in Oncology·Roberta RudàRiccardo Soffietti
Nov 24, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Marcel MatzenauerBohuslav Melichar
Jun 9, 2018·Frontiers in Oncology·Federica FranchinoRiccardo Soffietti
Feb 23, 2020·Nature Reviews. Clinical Oncology·John H SuhEric L Chang
Oct 13, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Philip J O'HalloranPaul Kongkham
Nov 17, 2020·Frontiers in Oncology·Fuxing ZuoJinghai Wan
Apr 4, 2021·Cancers·Martin A ProescholdtKarl-Michael Schebesch
Aug 9, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Le RhunUNKNOWN EANO Executive Board and ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Aug 21, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Klaus-Henning KahlGeorg Stüben
Aug 24, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philipp KarschniaJoerg-Christian Tonn

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.