PMID: 9531360Apr 8, 1998Paper

Impact of surgical staging in evaluating the radiotherapeutic outcome in RTOG #77-06, a phase III study for T1BN0M0 (A2) and T2N0M0 (B) prostate carcinoma

International Journal of Radiation Oncology, Biology, Physics
Sucha O AsbellMiljenko V Pilepich

Abstract

To evaluate survival and time to metastatic disease in patients treated for localized prostatic carcinoma in a Phase III radiotherapy (RT) protocol, Radiation Therapy Oncology Group (RTOG) 77-06. Patients with T18N0M0 (A2) or T2N0M0 (B) disease after lymphangiogram (LAG) or staging laparotomy (SL) were randomized between prophylactic radiation to the pelvic lymph nodes and prostatic bed vs. prostatic bed alone. The outcome of both treatment arms, as well as a comparison of the LAG group, to that of the SL group, are updated. A total of 449 eligible males were entered into RTOG protocol 7706 between 1978 and 1983. Lymph node staging was mandatory but at the physician's discretion; 117 (26%) patients had SL, while 332 (74%) had LAG. Follow-up was a median of 12 years and a maximum of 16 years. For those randomized to receive prophylactic pelvic lymph nodal irradiation, 45 Gy of megavoltage RT was delivered via multiple portals in 4.5-5 weeks, while all patients received 65 Gy in 6.5-8 weeks to the prostatic bed. There was no significant difference in survival whether treatment was administered to the prostate or prostate and pelvic lymph nodes. The SL group had greater 12-year survival than the LAG group (48% vs. 38%, p = 0.02). ...Continue Reading

References

Oct 1, 1992·Clinical Radiology·R ClementsW B Peeling
Mar 1, 1992·AJR. American Journal of Roentgenology·M L SchieblerE A Zerhouni
Apr 1, 1991·Disease-a-month : DM·R A Badalament, J R Drago
Oct 1, 1990·AJR. American Journal of Roentgenology·M K TerrisT A Stamey
Nov 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S O AsbellC A Perez
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·S O AsbellC A Perez
Aug 1, 1987·AJR. American Journal of Roentgenology·J F PlattR E Schwab
Jun 1, 1987·British Journal of Urology·P R HarnettP Duval
Sep 1, 1980·International Journal of Radiation Oncology, Biology, Physics·D G McGowan
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·G E HanksT F Pajak
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A V D'AmicoD Schultz
Jan 1, 1995·Seminars in Surgical Oncology·G van AndelT M de Reijke
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A L ZietmanW U Shipley
Nov 26, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A R MunkarahT W Burke

❮ Previous
Next ❯

Citations

Oct 12, 2011·Der Radiologe·S Krause, K Herfarth
Sep 25, 2008·Der Urologe. Ausg. A·K Herfarth, F Sterzing
Sep 3, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·O ChapetF Lorchel
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Sophie D FossåDag Rune Olsen
Feb 16, 1999·International Journal of Radiation Oncology, Biology, Physics·S A Leibel
Dec 31, 2002·Urologic Oncology·Tony Y EngTerrence S Herman
May 18, 1999·Current Opinion in Oncology·E J Small
Dec 1, 2005·American Journal of Clinical Oncology·Catherine T LeeDeborah A Kuban
May 30, 2013·La Radiologia medica·Berardino De BariUNKNOWN AIRO Young and AIRO Prostate cancer Working Group
Dec 18, 2007·Seminars in Radiation Oncology·Dian Wang, Colleen Lawton
Aug 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Arne BergSophie Dorothea Fosså
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·Arya AminiBrian D Kavanagh
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Pascal PommierChristian Carrie
Dec 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pascal PommierChristian Carrie
Mar 24, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Matthias G Hautmann, Oliver Kölbl
Apr 25, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Piet DirixHendrik Van Poppel
Dec 26, 2002·The Cancer Journal·Arthur Y HungDeborah A Kuban
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L L KestinF A Vicini
Apr 14, 2018·La Radiologia medica·Mauro LoiLorenzo Livi
Mar 9, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Imraan Jan, Rahul R Parikh
Aug 3, 2021·International Journal of Clinical Oncology·Rihito AizawaTakashi Mizowaki
May 29, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Barbara Alicja Jereczek-Fossa, Roberto Orecchia

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