Impact of sustained virologic response on risk of type 2 diabetes among hepatitis C patients in the United States

Journal of Viral Hepatitis
J LiCHeCS Investigators

Abstract

Data regarding the impact of hepatitis C (HCV) therapy on incidence of type 2 diabetes mellitus are limited. We used the data from the longitudinal Chronic Hepatitis Cohort Study-drawn from four large US health systems-to investigate how response to HCV treatment impacts the risk of subsequent diabetes. Among HCV patients without a history of type 2 diabetes mellitus or hepatitis B, we investigated the incidence of type 2 diabetes from 12 weeks post-HCV treatment through December 2015. Cox proportional hazards models were used to test the effect of treatment status (sustained virologic response [SVR] or treatment failure) and baseline risk factors on the development of diabetes, considering any possible risk factor-by-SVR interactions, and death as a competing risk. Among 5127 patients with an average follow-up of 3.7 years, diabetes incidence was significantly lower among patients who achieved SVR (231/3748; 6.2%) than among patients with treatment failure (299/1379; 21.7%; adjusted hazard ratio [aHR] = 0.79; 95% CI: 0.65-0.96). Risk of diabetes was higher among African American and Asian American patients than White patients (aHR = 1.82 and 1.75, respectively; P < .05), and among Hispanic patients than non-Hispanics (aHR = 1....Continue Reading

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Citations

Aug 2, 2018·Expert Review of Anti-infective Therapy·Simone LaniniGiuseppe Ippolito
Jan 17, 2019·Alimentary Pharmacology & Therapeutics·Jia LiUNKNOWN CHeCS Investigators
Apr 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtAbdul-Badi Abou-Samra
Jan 10, 2020·Journal of Diabetes Research·Yingying ZhaoShibo Ji
Apr 17, 2019·Clinical Liver Disease·Syed-Mohammed Jafri, Stuart C Gordon
Aug 23, 2020·Journal of Clinical Medicine·Christiana GrafUlrike Mihm
Jan 6, 2021·The American Journal of Gastroenterology·Jia LiUNKNOWN CHeCS Investigators
May 20, 2021·World Journal of Gastroenterology : WJG·Mohamed ShengirGiada Sebastiani
Dec 16, 2021·Revista da Associação Médica Brasileira·Manuela Maria de Lima CarvalhalJuarez Antônio Simões Quaresma

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