PMID: 8957379Dec 1, 1996Paper

Impact of systemic depulsation on tissue perfusion and sympathetic nerve activity

The Annals of Thoracic Surgery
K TodaH Takano

Abstract

We postulated that pathophysiologic processes under nonpulsatile circulation are related to the behavior of the sympathetic nerve activity that regulates tissue perfusion. Pulsatile and nonpulsatile pumps were installed in parallel in the left heart bypass circuit of anesthetized goats (n = 9) so that pulsatile circulation could be converted to nonpulsatile circulation instantly. At 5 minutes before and after systemic depulsation, we measured hemodynamic indices, renal nerve activity, and regional blood flow of the brain, heart, and renal cortex. Renal nerve activity was significantly elevated after systemic depulsation (15.6 +/- 9.3 versus 19.4 +/- 9.8 microV), when mean aortic pressure remained almost constant. The renal cortical flow was significantly reduced after depulsation (3.61 +/- 1.23 versus 2.93 +/- 1.19 mL.min-1.g-1), whereas no significant difference was found in the regional blood flow of the brain or the heart. The significant reduction of renal cortical blood flow after systemic depulsation is associated with a significant increase in renal nerve activity. Our results suggest that increased renal nerve activity plays an important role in the reduction of renal function after systemic depulsation.

References

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Citations

Dec 18, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E V PotapovR Hetzer
Apr 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodger LoutzenhiserAnil Bidani
Oct 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuhiko HayashidaShigeaki Aoyagi
Jun 19, 2004·Scandinavian Cardiovascular Journal : SCJ·Kunihide NakamuraRobert Whalen
Jun 5, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elzbieta PolskaLeopold Schmetterer
Aug 28, 2004·Autonomic Neuroscience : Basic & Clinical·Bernat Kocsis, Katalin Gyimesi-Pelczer
Mar 10, 2015·The Canadian Journal of Cardiology·Liza Grosman-RimonVivek Rao
Apr 18, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Aldo Domenico MilanoGiuseppe Faggian
Nov 29, 2016·Expert Review of Medical Devices·Gengo SunagawaKiyotaka Fukamachi
Jan 30, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adeline RaignaultEric Thorin
Mar 5, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kazuhiro EyaKamuran Kadipasaoglu
Mar 26, 2003·The International Journal of Artificial Organs·H SchimaK Perktold

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