Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: A meta-analysis of studies published between years 2001-2016

Journal of Autoimmunity
Pravesh Kumar BundhunFeng Huang

Abstract

Previous research has already shown systemic lupus erythematosus (SLE) to have severe consequences on pregnancy outcomes. However, insufficient number of participants, which were mainly limited to one particular region, limited outcomes analyzed and lack of evidence based analysis to support systematic reviews of the literature were the limitations observed. Therefore, by improving these limitations, we aimed to systematically show the impact of SLE on maternal and fetal outcomes following pregnancy. The Cochrane Database of Randomized Controlled Trials, EMBASE and Medline databases were carefully searched for appropriately relevant English language studies comparing maternal and/or fetal outcomes (endpoints) in pregnant women with and without SLE. With the presence of discontinuous data, risk ratios (RR) and 95% confidence intervals (CI) were calculated and the final analysis was carried out by RevMan 5.3 software. Eleven studies with a total number of 529,778 participants were included. This current analysis showed cesarean operation to be significantly higher in patients with SLE (RR: 1.85, 95% CI: 1.63-2.10; P = 0.00001). Pre-eclampsia and hypertension also significantly affected women with SLE, (RR: 1.91, 95% CI: 1.44-2.53...Continue Reading

Citations

May 24, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shigeo Iijima
Jul 6, 2017·Current Opinion in Rheumatology·Laura AndreoliAngela Tincani
Feb 19, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nicolas BelhommePatrick Jego
Jan 25, 2019·Current Opinion in Obstetrics & Gynecology·Samantha C Do, Maurice L Druzin
Jun 13, 2019·Nature Reviews. Rheumatology·Ian GilesCaroline Gordon
Jun 7, 2019·Current Opinion in Rheumatology·Luis J JaraMiguel A Saavedra
Aug 26, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·Z ZhangH-Y Jiang
Oct 29, 2019·Expert Opinion on Drug Safety·Leanna M Wise, William Stohl
Dec 4, 2019·Expert Review of Clinical Immunology·May ChoiLeslie Skeith
Dec 13, 2019·Zeitschrift für Rheumatologie·R Fischer-Betz, S Späthling-Mestekemper
Sep 5, 2019·Modern Rheumatology·Sayaka TsudaUNKNOWN Ministry of Health Labour and Welfare Working Group for “Guideline for The Treatment of Rheumatoid Arthritis or Inflammatory
Apr 10, 2019·The Journal of Experimental Medicine·Seunghee HongVirginia Pascual
May 31, 2017·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Sep 8, 2018·Zeitschrift für Rheumatologie·Sabine Adler
Nov 2, 2019·BMC Nephrology·Kate WilesKate Bramham
Apr 1, 2020·International Journal of Rheumatic Diseases·Miguel Ángel SaavedraLuis Javier Jara
Jul 28, 2018·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Jun 27, 2020·The Journal of International Medical Research·Min HouYi-Hua He
Dec 17, 2020·Lupus·Karel VenneEvelyne Vinet
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Stefano CelottoJacopo Demurtas
Nov 3, 2020·Frontiers in Immunology·Bahaa Abu-RayaPascal M Lavoie
Feb 19, 2021·Expert Opinion on Drug Safety·Anna Viola TaulaigoLaura Andreoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.