Previous research has already shown systemic lupus erythematosus (SLE) to have severe consequences on pregnancy outcomes. However, insufficient number of participants, which were mainly limited to one particular region, limited outcomes analyzed and lack of evidence based analysis to support systematic reviews of the literature were the limitations observed. Therefore, by improving these limitations, we aimed to systematically show the impact of SLE on maternal and fetal outcomes following pregnancy. The Cochrane Database of Randomized Controlled Trials, EMBASE and Medline databases were carefully searched for appropriately relevant English language studies comparing maternal and/or fetal outcomes (endpoints) in pregnant women with and without SLE. With the presence of discontinuous data, risk ratios (RR) and 95% confidence intervals (CI) were calculated and the final analysis was carried out by RevMan 5.3 software. Eleven studies with a total number of 529,778 participants were included. This current analysis showed cesarean operation to be significantly higher in patients with SLE (RR: 1.85, 95% CI: 1.63-2.10; P = 0.00001). Pre-eclampsia and hypertension also significantly affected women with SLE, (RR: 1.91, 95% CI: 1.44-2.53...Continue Reading
Pregnancy outcome in systemic lupus erythematosus (SLE) is improving: Results from a case control study and literature review
Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study
Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus
Long-Term Outcomes of Systemic Lupus Erythematous Patients after Pregnancy: A Nationwide Population-Based Cohort Study
Pregnancy outcomes among women with systemic lupus erythematosus: a retrospective cohort study from Thailand
The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus
Increased circulating interleukin-8 levels in systemic lupus erythematosus patients: a meta-analysis
Clinical outcomes and predictors of maternal and fetal complications in pregnancies of patients with systemic lupus erythematosus
Patterns of medication use before, during and after pregnancy in women with systemic lupus erythematosus: a population-based cohort study
Trends in Maternal and Fetal Outcomes Among Pregnant Women With Systemic Lupus Erythematosus in the United States: A Cross-sectional Analysis
The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis
Managing pregnancy-associated clinical emergencies in systemic lupus erythematosus: a case-based approach.
Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study
The effect of parity, history of preeclampsia, and pregnancy care on the incidence of subsequent preeclampsia in multiparous women with SLE.
Arterial/venous thrombosis, fetal loss and stillbirth in pregnant women with systemic lupus erythematosus versus primary and secondary antiphospholipid syndrome: a systematic review and meta-analysis
The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus
Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study
Risk of gestational diabetes mellitus in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis
Hypertensive disorders of pregnancy associated with adverse pregnant outcomes in patients with systemic lupus erythematosus: a multicenter retrospective study
Maternal rheumatoid arthritis and systemic lupus erythematosus and risk of cryptorchidism and hypospadias in boys: a Danish nationwide study
Use of antimalarial drugs is associated with a lower risk of preeclampsia in lupus pregnancy: A prospective cohort study.
Maternal and fetal complications associated with systemic lupus erythematosus: An updated meta-analysis of the most recent studies (2017-2019)
Unchanging premature mortality trends in systemic lupus erythematosus: a general population-based study (1999-2014)
Pregnancy outcomes in patients with primary antiphospholipid syndrome: A systematic review and meta-analysis
Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study
Treatment and follow-up of fetuses that developed congenital heart block due to autoantibody in two cases
A preeclampsia risk prediction model for Chinese pregnant patients with systemic lupus erythematosus
Risk factors associated with adverse pregnancy outcomes in patients with new-onset systemic lupus erythematosus during pregnancy.
An umbrella review of systematic reviews with meta-analyses evaluating positive and negative outcomes of Hydroxychloroquine and chloroquine therapy.
Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: A nationwide population-based study.
Factors affecting the Apgar score of offsprings born to mothers suffering from systemic lupus erythematosus.
Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus: A STROBE-compliant study.
Breastfeeding in women affected by systemic lupus erythematosus: Rate, duration and associated factors.
The presence of lupus nephritis additionally increases the risk of preeclampsia among pregnant women with systemic lupus erythematosus.
Hydroxychloroquine prophylaxis for preeclampsia, hypertension and prematurity in pregnant patients with systemic lupus erythematosus: A meta-analysis.
Multidisciplinary Unit Improves Pregnancy Outcomes in Women with Rheumatic Diseases and Hereditary Thrombophilias: An Observational Study.
Lupus Low Disease Activity State Achievement Is Important for Reducing Adverse Outcomes in Pregnant Patients With Systemic Lupus Erythematosus.
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.