Abstract
Atrial fibrillation recurrences after pulmonary vein isolation (PVI) are not uncommon and are frequently related to pulmonary vein reconnection. Adenosine/ATP can reveal dormant pulmonary vein conduction after PVI. Previous studies revealed that adenosine-guided Additional ablation could improve arrhythmia-free survival. We performed a meta-analysis to assess the impact of additional ablation to eliminate adenosine-induced transient pulmonary vein reconnection in terms of atrial fibrillation recurrence at follow-up. MEDLINE/PubMed, Cochrane Library and references reporting atrial fibrillation ablation and adenosine/ATP-following PVI were screened, and studies were included if they matched inclusion and exclusion criteria. A total of 3524 patients were enrolled with a median follow-up of 13 (6-20) months. Overall, 70% (60-85) of patients in ATP-guided ablation vs. 63% (48-79) in no ATP-guided ablation were free of atrial fibrillation at follow-up. Pooled results revealed that ATP-guided ablation reduced the risk of atrial fibrillation recurrence of 42% [odds ratio (OR) 0.58, 0.41-0.81], but this result was primary because of the contribution of retrospective over-randomized studies [OR 0.48 (0.35-0.65) vs. 0.76 (0.42-1.40), resp...Continue Reading
References
Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
May 2, 2000·JAMA : the Journal of the American Medical Association·D F StroupS B Thacker
Apr 17, 2001·Annals of Internal Medicine·D G AltmanUNKNOWN CONSORT GROUP (Consolidated Standards of Reporting Trials)
Sep 15, 2004·Journal of Cardiovascular Electrophysiology·Thomas ArentzMichel Haissaguerre
Dec 30, 2004·Circulation·Feifan OuyangKarl-Heinz Kuck
Feb 9, 2007·Journal of Cardiovascular Electrophysiology·Hitoshi HachiyaYoshito Iesaka
May 18, 2007·Journal of Cardiovascular Electrophysiology·Seiichiro MatsuoSeibu Mochizuki
Jul 19, 2008·Journal of the American College of Cardiology·Thomas NeumannHeinz-Friedrich Pitschner
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Oct 3, 2009·Journal of the American College of Cardiology·Christoph ScharfFred Morady
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Fiorenzo GaitaCarla Giustetto
Dec 22, 2009·Journal of Cardiovascular Electrophysiology·Koji KumagaiKoichi Taniguchi
Feb 18, 2010·Circulation·Tomás DatinoStanley Nattel
Apr 5, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jason G AndradeMarc Dubuc
Sep 26, 2012·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·Y L E Van BelleL J Jordaens
Nov 1, 2012·Journal of Cardiovascular Electrophysiology·Yves De GreefMattias Duytschaever
Mar 16, 2013·Journal of Cardiovascular Electrophysiology·Alex J A McLellanPeter M Kistler
May 15, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Narendra KumarHarry J Crijns
Jul 28, 2015·Lancet·Laurent MacleUNKNOWN ADVICE trial investigators
Aug 19, 2015·Circulation·Armin LuikClaus Schmitt
Oct 13, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hamid GhanbariAman Chugh
Citations
Oct 16, 2018·Journal of Cardiovascular Medicine·Susanna MaltoniGiuseppe Boriani
Oct 16, 2018·Cardiovascular & Hematological Disorders Drug Targets·Trevor SimardBenjamin Hibbert
Nov 13, 2019·Herzschrittmachertherapie & Elektrophysiologie·Clemens Jilek, Thorsten Lewalter