Impact of the antiretroviral treatment program on the burden of hospitalization for culture-confirmed tuberculosis in South African children: a time-series analysis

The Pediatric Infectious Disease Journal
Ziyaad DangorShabir A Madhi

Abstract

The HIV epidemic increased the burden of tuberculosis (TB) in sub-Saharan Africa. We evaluated the impact that scaling-up of the public-funded antiretroviral treatment (ART) program had on incidence of hospitalization for culture-confirmed and overall-TB in HIV-infected and HIV-uninfected children from 2005 to 2009. The study was undertaken in Soweto, South Africa, where ART coverage of HIV-infected children increased from 43% in 2005 to 84% by 2009. Trends in incidence of hospitalization for clinically diagnosed and culture-confirmed TB in children 3 months to <15 years of age, identified through laboratory and electronic databases, were analyzed by comparing crude incidence and regression analysis. The incidence (per 100,000) of culture-confirmed TB declined by 63.1% from 2005 (69.8) compared with 2009 (25.8; P < 0.0001). This included a 70.6% reduction between 2005 and 2009 among HIV-infected children (incidence: 1566.3 versus 460.7, respectively; P < 0.0001) and 41.3% decrease in HIV-uninfected children (18.7 versus 11.0, respectively; P = 0.0003). The month-by-month rate of decline of culture-confirmed TB was 2.3% in HIV-infected and 1.1% in HIV-uninfected children over the study period. The residual burden of TB remained ...Continue Reading

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Citations

Feb 26, 2014·BMC Infectious Diseases·Elisabetta VenturiniClaire Thorne
Jul 12, 2017·Journal of the International AIDS Society·Linda Barlow-MoshaMartina Penazzato
Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Dec 8, 2015·Journal of the International AIDS Society·Helena RabieAnthony J Garcia-Prats
Jul 14, 2017·Pneumonia·Helena Rabie, Pierre Goussard
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David P MooreShabir A Madhi
Apr 4, 2021·International Journal of Molecular Sciences·Sonia Romero-CorderoConstanza Morén
Apr 8, 2017·Microbiology Spectrum·Gabriella S Lamb, Jeffrey R Starke

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